Fluidizing effects of centrophenoxine in vitro on brain and liver membranes from different age groups of mice

W. Gibson Wood; Christine Gorka; H. James Armbrecht; Lisa S. Williamson; Randy Strong

doi:10.1016/0024-3205(86)90360-7

Fluidizing effects of centrophenoxine in vitro on brain and liver membranes from different age groups of mice

W. Gibson Wood, Christine Gorka, H. James Armbrecht, Lisa S. Williamson, Randy Strong

Pharmacology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

This study examined the effects of different concentrations of centrophenoxine on physical properties of synaptic plasma membranes and liver microsomes using electron spin resonance procedures. Membranes of different age groups of mice were labeled with the 5-doxyl stearic acid spin-label and membrane fluidity determined in the presence and absence of different concentrations of centrophenoxine. Centrophenoxine had a direct effect on membranes as shown by a significant increase in membrane fluidity. This effect was greatest in liver microsomes as compared to synaptic plasma membranes. Age differences were not observed in centrophenoxine-induced fluidization. Effects of centrophenoxine in vivo may be due in part to the drug acting directly on the physical properties of the membrane lipid environment.

Original language	English (US)
Pages (from-to)	2089-2095
Number of pages	7
Journal	Life Sciences
Volume	39
Issue number	22
DOIs	https://doi.org/10.1016/0024-3205(86)90360-7
State	Published - Dec 1 1986

Bibliographical note

Funding Information:
This work was supported by the Medical Research Service of the Veterans Administration, USPHS Grant AA-02054 and the Geriatric Research, Education, and Clinical Center of the St. Louis Veterans Administration Medical Center. The authors gratefully acknowledge the excellent secretarial assistance of Cheryl Mason.

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title = "Fluidizing effects of centrophenoxine in vitro on brain and liver membranes from different age groups of mice",

abstract = "This study examined the effects of different concentrations of centrophenoxine on physical properties of synaptic plasma membranes and liver microsomes using electron spin resonance procedures. Membranes of different age groups of mice were labeled with the 5-doxyl stearic acid spin-label and membrane fluidity determined in the presence and absence of different concentrations of centrophenoxine. Centrophenoxine had a direct effect on membranes as shown by a significant increase in membrane fluidity. This effect was greatest in liver microsomes as compared to synaptic plasma membranes. Age differences were not observed in centrophenoxine-induced fluidization. Effects of centrophenoxine in vivo may be due in part to the drug acting directly on the physical properties of the membrane lipid environment.",

author = "{Gibson Wood}, W. and Christine Gorka and {James Armbrecht}, H. and Williamson, {Lisa S.} and Randy Strong",

note = "Funding Information: This work was supported by the Medical Research Service of the Veterans Administration, USPHS Grant AA-02054 and the Geriatric Research, Education, and Clinical Center of the St. Louis Veterans Administration Medical Center. The authors gratefully acknowledge the excellent secretarial assistance of Cheryl Mason.",

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T1 - Fluidizing effects of centrophenoxine in vitro on brain and liver membranes from different age groups of mice

AU - Gibson Wood, W.

AU - Gorka, Christine

AU - James Armbrecht, H.

AU - Williamson, Lisa S.

AU - Strong, Randy

N1 - Funding Information: This work was supported by the Medical Research Service of the Veterans Administration, USPHS Grant AA-02054 and the Geriatric Research, Education, and Clinical Center of the St. Louis Veterans Administration Medical Center. The authors gratefully acknowledge the excellent secretarial assistance of Cheryl Mason.

PY - 1986/12/1

Y1 - 1986/12/1

N2 - This study examined the effects of different concentrations of centrophenoxine on physical properties of synaptic plasma membranes and liver microsomes using electron spin resonance procedures. Membranes of different age groups of mice were labeled with the 5-doxyl stearic acid spin-label and membrane fluidity determined in the presence and absence of different concentrations of centrophenoxine. Centrophenoxine had a direct effect on membranes as shown by a significant increase in membrane fluidity. This effect was greatest in liver microsomes as compared to synaptic plasma membranes. Age differences were not observed in centrophenoxine-induced fluidization. Effects of centrophenoxine in vivo may be due in part to the drug acting directly on the physical properties of the membrane lipid environment.

AB - This study examined the effects of different concentrations of centrophenoxine on physical properties of synaptic plasma membranes and liver microsomes using electron spin resonance procedures. Membranes of different age groups of mice were labeled with the 5-doxyl stearic acid spin-label and membrane fluidity determined in the presence and absence of different concentrations of centrophenoxine. Centrophenoxine had a direct effect on membranes as shown by a significant increase in membrane fluidity. This effect was greatest in liver microsomes as compared to synaptic plasma membranes. Age differences were not observed in centrophenoxine-induced fluidization. Effects of centrophenoxine in vivo may be due in part to the drug acting directly on the physical properties of the membrane lipid environment.

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JF - Life Sciences

SN - 0024-3205

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ER -

Fluidizing effects of centrophenoxine in vitro on brain and liver membranes from different age groups of mice

Abstract

Bibliographical note

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