Flu-like symptoms associated with fluoxetine overdose: A case report

Suck Won Kim, Paul R. Pentel

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The serotonin reuptake inhibitor zimelidine may cause flu-like symptoms and Guillain-Barre syndrome. Guillain-Barre syndrome has not been reported with the use of the structurally related serotonin reuptake inhibitor fluoxetine. Flu-like symptoms are described in the manufacturer's literature on fluoxetine but are absent from published studies. We describe a patient who developed flu-like symptoms, urticaria and angioedema 2 days after fluoxetine overdose. There were no neurologic sequelae. This case confirms that fluoxetine may be associated with flu-like symptoms and suggests that, because these symptoms occurred after overdose, they may be dose related. The additional findings in this patient suggestive of allergy, an unusual feature of drug overdose, are discussed.

Original languageEnglish (US)
Pages (from-to)389-393
Number of pages5
JournalClinical Toxicology
Issue number6
StatePublished - 1989

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Copyright 2014 Elsevier B.V., All rights reserved.


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