Flow-rate dependence of post-column reaction chromatographic detectors and optimization of reactor length for slow chemical reactions

Y. T. Shih, Peter W. Carr

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

In high-performance liquid chromatography, use of any post-column reactor invariably involves a compromise between the conditions needed to obtain complete reaction and avoidance of excessive dispersion by band broadening in the reactor. Flow rate and the reactor geometry interact to establish the final chromatographic performance. Based on the flow-rate dependence of the peak area and peak height, post-column detectors constitute a distinct class of detectors which differ from mass-flow and concentrations-sensitive detectors such as the flame ionization and absorbance detector, respectively. The concept of reactor length optimization is developed for first-order chemical reactions in a post-column detector. The findings are applicable to both chromatographic and flow-injection systems.

Original languageEnglish (US)
Pages (from-to)137-144
Number of pages8
JournalAnalytica Chimica Acta
Volume167
Issue numberC
DOIs
StatePublished - 1985

Fingerprint Dive into the research topics of 'Flow-rate dependence of post-column reaction chromatographic detectors and optimization of reactor length for slow chemical reactions'. Together they form a unique fingerprint.

Cite this