TY - JOUR
T1 - Flecainide versus quinidine
T2 - Results of a multicenter trial
AU - Hodges, Morrison
AU - Salerno, David M.
AU - Granrud, Gregory
PY - 1984/2/27
Y1 - 1984/2/27
N2 - In this multicenter trial, the efficacy and safety of flecainide, a new antiarrhythmic agent, were compared with those of quinidine, a standard antiarrhythmic agent in the United States. A randomized, parallel, placebo-controlled design was used. Flecainide was more effective than quinidine (p < 0.0001) in reducing ventricular premature complexes, couplets and ventricular tachycardia. Flecainide continued to be effective in reducing ventricular arrhythmias during a 12-month follow-up period. The incidence of side effects was similar for the 2 drugs in both short- and long-term studies. Therefore, flecainide should be an excellent drug to use in treating patients with ventricular arrhythmias classified as either benign or potentially malignant.
AB - In this multicenter trial, the efficacy and safety of flecainide, a new antiarrhythmic agent, were compared with those of quinidine, a standard antiarrhythmic agent in the United States. A randomized, parallel, placebo-controlled design was used. Flecainide was more effective than quinidine (p < 0.0001) in reducing ventricular premature complexes, couplets and ventricular tachycardia. Flecainide continued to be effective in reducing ventricular arrhythmias during a 12-month follow-up period. The incidence of side effects was similar for the 2 drugs in both short- and long-term studies. Therefore, flecainide should be an excellent drug to use in treating patients with ventricular arrhythmias classified as either benign or potentially malignant.
UR - http://www.scopus.com/inward/record.url?scp=0021352511&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021352511&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(84)90505-8
DO - 10.1016/0002-9149(84)90505-8
M3 - Article
C2 - 6364770
AN - SCOPUS:0021352511
SN - 0002-9149
VL - 53
SP - B66-B71
JO - The American Journal of Cardiology
JF - The American Journal of Cardiology
IS - 5
ER -