Flavor enhances the antidipsogenic effect of naloxone

Allen S Levine, Samuel S. Murray, Julie Kneip, Martha Grace, John E. Morley

Research output: Contribution to journalArticlepeer-review

131 Scopus citations

Abstract

Naloxone suppressed ingestion of tap water following a 15 hour deprivation at doses of 20, 10 and 5 mg/kg. Addition of saccharine (0.2%), saline (0.8%), sucrose (2%) and HCl (0.1 M) to tap water resulted in an increased sensitivity to naloxone-induced suppression of water intake following the 15 hour deprivation. The volume of quinine solution (0.1%) consumed was not altered by administration of naloxone. We suggest that naloxone suppresses drinking behavior due to alterations in taste perception.

Original languageEnglish (US)
Pages (from-to)23-25
Number of pages3
JournalPhysiology and Behavior
Volume28
Issue number1
DOIs
StatePublished - Jan 1982

Keywords

  • Drinking
  • Flavor
  • Naloxone
  • Oropharyngeal factors
  • Taste
  • Water deprivation

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