Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia

Eun jin Cheon, Alie G. Male, Bingchen Gao, Bhim M. Adhikari, Jesse T. Edmond, Stephanie M. Hare, Aysenil Belger, Steven G. Potkin, Juan R. Bustillo, Daniel H. Mathalon, Judith M. Ford, Kelvin O. Lim, Bryon A. Mueller, Adrian Preda, Daniel O'Leary, Gregory P. Strauss, Anthony O. Ahmed, Paul M. Thompson, Neda Jahanshad, Peter KochunovVince D. Calhoun, Jessica A. Turner, Theo G.M. van Erp

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


This study examined associations between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms represented by total scores, second-order dimension (motivation and pleasure, expressivity), and first-order domain (anhedonia, avolition, asociality, alogia, blunted affect) factor scores in schizophrenia (n = 57). Total negative symptom scores showed positive associations with ALFF in temporal and frontal brain regions. Negative symptom domain scores showed predominantly stronger associations with regional ALFF compared to total scores, suggesting domain scores may better map to neural signatures than total scores. Improving our understanding of the neuropathology underlying negative symptoms may aid in addressing this unmet therapeutic need in schizophrenia.

Original languageEnglish (US)
Article number111597
JournalPsychiatry Research - Neuroimaging
StatePublished - Mar 2023

Bibliographical note

Funding Information:
This study was supported by was supported by the National Center for Research Resources at the National Institutes of Health [grant numbers: NIH 1 U24 RR021992 (Function Biomedical Informatics Research Network), NIH 1 U24 RR025736 (Biomedical Informatics Research Network Coordinating Center)], National Institutes of Health [grant numbers: 1R01MH121246 (ENIGMA-COINSTAC: Advanced Worldwide Transdiagnostic Analysis of Valence System Brain Circuits to JAT, TGMvE, and VDC, and R01MH118695 to VDC), the National Science Foundation [grant number: NSF 2112455 to VDC], and a Veterans Affairs Distinguished Research Career Scientist to JMF. The funding sources had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.

Publisher Copyright:
© 2023


  • ALFF
  • Avolition
  • Negative symptoms


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