Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia

Eun jin Cheon; Alie G. Male; Bingchen Gao; Bhim M. Adhikari; Jesse T. Edmond; Stephanie M. Hare; Aysenil Belger; Steven G. Potkin; Juan R. Bustillo; Daniel H. Mathalon; Judith M. Ford; Kelvin O. Lim; Bryon A. Mueller; Adrian Preda; Daniel O'Leary; Gregory P. Strauss; Anthony O. Ahmed; Paul M. Thompson; Neda Jahanshad; Peter Kochunov; Vince D. Calhoun; Jessica A. Turner; Theo G.M. van Erp

doi:10.1016/j.pscychresns.2023.111597

Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia

Eun jin Cheon, Alie G. Male, Bingchen Gao, Bhim M. Adhikari, Jesse T. Edmond, Stephanie M. Hare, Aysenil Belger, Steven G. Potkin, Juan R. Bustillo, Daniel H. Mathalon, Judith M. Ford, Kelvin O. Lim, Bryon A. Mueller, Adrian Preda, Daniel O'Leary, Gregory P. Strauss, Anthony O. Ahmed, Paul M. Thompson, Neda Jahanshad, Peter KochunovVince D. Calhoun, Jessica A. Turner, Theo G.M. van Erp

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

This study examined associations between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms represented by total scores, second-order dimension (motivation and pleasure, expressivity), and first-order domain (anhedonia, avolition, asociality, alogia, blunted affect) factor scores in schizophrenia (n = 57). Total negative symptom scores showed positive associations with ALFF in temporal and frontal brain regions. Negative symptom domain scores showed predominantly stronger associations with regional ALFF compared to total scores, suggesting domain scores may better map to neural signatures than total scores. Improving our understanding of the neuropathology underlying negative symptoms may aid in addressing this unmet therapeutic need in schizophrenia.

Original language	English (US)
Article number	111597
Journal	Psychiatry Research - Neuroimaging
Volume	329
DOIs	https://doi.org/10.1016/j.pscychresns.2023.111597
State	Published - Mar 2023

Bibliographical note

Funding Information:
This study was supported by was supported by the National Center for Research Resources at the National Institutes of Health [grant numbers: NIH 1 U24 RR021992 (Function Biomedical Informatics Research Network), NIH 1 U24 RR025736 (Biomedical Informatics Research Network Coordinating Center)], National Institutes of Health [grant numbers: 1R01MH121246 (ENIGMA-COINSTAC: Advanced Worldwide Transdiagnostic Analysis of Valence System Brain Circuits to JAT, TGMvE, and VDC, and R01MH118695 to VDC), the National Science Foundation [grant number: NSF 2112455 to VDC], and a Veterans Affairs Distinguished Research Career Scientist to JMF. The funding sources had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.

Publisher Copyright:
© 2023

Keywords

ALFF
Avolition
Negative symptoms

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pscychresns.2023.111597

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Cheon, E. J., Male, A. G., Gao, B., Adhikari, B. M., Edmond, J. T., Hare, S. M., Belger, A., Potkin, S. G., Bustillo, J. R., Mathalon, D. H., Ford, J. M., Lim, K. O., Mueller, B. A., Preda, A., O'Leary, D., Strauss, G. P., Ahmed, A. O., Thompson, P. M., Jahanshad, N., ... van Erp, T. G. M. (2023). Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia. Psychiatry Research - Neuroimaging, 329, [111597]. https://doi.org/10.1016/j.pscychresns.2023.111597

Cheon, EJ, Male, AG, Gao, B, Adhikari, BM, Edmond, JT, Hare, SM, Belger, A, Potkin, SG, Bustillo, JR, Mathalon, DH, Ford, JM, Lim, KO , Mueller, BA, Preda, A, O'Leary, D, Strauss, GP, Ahmed, AO, Thompson, PM, Jahanshad, N, Kochunov, P, Calhoun, VD, Turner, JA & van Erp, TGM 2023, 'Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia', Psychiatry Research - Neuroimaging, vol. 329, 111597. https://doi.org/10.1016/j.pscychresns.2023.111597

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title = "Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia",

abstract = "This study examined associations between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms represented by total scores, second-order dimension (motivation and pleasure, expressivity), and first-order domain (anhedonia, avolition, asociality, alogia, blunted affect) factor scores in schizophrenia (n = 57). Total negative symptom scores showed positive associations with ALFF in temporal and frontal brain regions. Negative symptom domain scores showed predominantly stronger associations with regional ALFF compared to total scores, suggesting domain scores may better map to neural signatures than total scores. Improving our understanding of the neuropathology underlying negative symptoms may aid in addressing this unmet therapeutic need in schizophrenia.",

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author = "Cheon, {Eun jin} and Male, {Alie G.} and Bingchen Gao and Adhikari, {Bhim M.} and Edmond, {Jesse T.} and Hare, {Stephanie M.} and Aysenil Belger and Potkin, {Steven G.} and Bustillo, {Juan R.} and Mathalon, {Daniel H.} and Ford, {Judith M.} and Lim, {Kelvin O.} and Mueller, {Bryon A.} and Adrian Preda and Daniel O'Leary and Strauss, {Gregory P.} and Ahmed, {Anthony O.} and Thompson, {Paul M.} and Neda Jahanshad and Peter Kochunov and Calhoun, {Vince D.} and Turner, {Jessica A.} and {van Erp}, {Theo G.M.}",

note = "Funding Information: This study was supported by was supported by the National Center for Research Resources at the National Institutes of Health [grant numbers: NIH 1 U24 RR021992 (Function Biomedical Informatics Research Network), NIH 1 U24 RR025736 (Biomedical Informatics Research Network Coordinating Center)], National Institutes of Health [grant numbers: 1R01MH121246 (ENIGMA-COINSTAC: Advanced Worldwide Transdiagnostic Analysis of Valence System Brain Circuits to JAT, TGMvE, and VDC, and R01MH118695 to VDC), the National Science Foundation [grant number: NSF 2112455 to VDC], and a Veterans Affairs Distinguished Research Career Scientist to JMF. The funding sources had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = mar,

doi = "10.1016/j.pscychresns.2023.111597",

language = "English (US)",

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T1 - Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia

AU - Cheon, Eun jin

AU - Male, Alie G.

AU - Gao, Bingchen

AU - Adhikari, Bhim M.

AU - Edmond, Jesse T.

AU - Hare, Stephanie M.

AU - Belger, Aysenil

AU - Potkin, Steven G.

AU - Bustillo, Juan R.

AU - Mathalon, Daniel H.

AU - Ford, Judith M.

AU - Lim, Kelvin O.

AU - Mueller, Bryon A.

AU - Preda, Adrian

AU - O'Leary, Daniel

AU - Strauss, Gregory P.

AU - Ahmed, Anthony O.

AU - Thompson, Paul M.

AU - Jahanshad, Neda

AU - Kochunov, Peter

AU - Calhoun, Vince D.

AU - Turner, Jessica A.

AU - van Erp, Theo G.M.

N1 - Funding Information: This study was supported by was supported by the National Center for Research Resources at the National Institutes of Health [grant numbers: NIH 1 U24 RR021992 (Function Biomedical Informatics Research Network), NIH 1 U24 RR025736 (Biomedical Informatics Research Network Coordinating Center)], National Institutes of Health [grant numbers: 1R01MH121246 (ENIGMA-COINSTAC: Advanced Worldwide Transdiagnostic Analysis of Valence System Brain Circuits to JAT, TGMvE, and VDC, and R01MH118695 to VDC), the National Science Foundation [grant number: NSF 2112455 to VDC], and a Veterans Affairs Distinguished Research Career Scientist to JMF. The funding sources had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. Publisher Copyright: © 2023

PY - 2023/3

Y1 - 2023/3

N2 - This study examined associations between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms represented by total scores, second-order dimension (motivation and pleasure, expressivity), and first-order domain (anhedonia, avolition, asociality, alogia, blunted affect) factor scores in schizophrenia (n = 57). Total negative symptom scores showed positive associations with ALFF in temporal and frontal brain regions. Negative symptom domain scores showed predominantly stronger associations with regional ALFF compared to total scores, suggesting domain scores may better map to neural signatures than total scores. Improving our understanding of the neuropathology underlying negative symptoms may aid in addressing this unmet therapeutic need in schizophrenia.

AB - This study examined associations between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms represented by total scores, second-order dimension (motivation and pleasure, expressivity), and first-order domain (anhedonia, avolition, asociality, alogia, blunted affect) factor scores in schizophrenia (n = 57). Total negative symptom scores showed positive associations with ALFF in temporal and frontal brain regions. Negative symptom domain scores showed predominantly stronger associations with regional ALFF compared to total scores, suggesting domain scores may better map to neural signatures than total scores. Improving our understanding of the neuropathology underlying negative symptoms may aid in addressing this unmet therapeutic need in schizophrenia.

KW - ALFF

KW - Avolition

KW - Negative symptoms

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SN - 0925-4927

VL - 329

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

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ER -

Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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