Fish oil improves arterial compliance in non-insulin-dependent diabetes mellitus

Gary E. McVeigh, Geraldine M. Brennan, Jay N Cohn, Stanley M Finkelstein, Randal J. Hayes, George D. Johnston

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

In a double-blind, placebo-controlled study we investigated the effects of dietary fish oil supplementation on arterial wall characteristics in 20 patients with non-insulin-dependent diabetes mellitus. Estimates reflecting compliance values in the large arteries and more peripheral vasculature, as measured by pulse-contour analysis, improved significantly after 6 weeks of fish oil therapy compared with values recorded at baseline and after 6 weeks' administration of olive oil. The large-artery compliance estimate increased from 1.50 (confidence interval [CI], 1.31 to 1.69) mL/mm Hg at baseline to 1.68 (CI, 1.52 to 1.84) mL/mm Hg after fish oil administration (P<.01). The oscillatory compliance value increased from 0.015 (CI, 0.011 to 0.019) mL/mm Hg at baseline to 0.022 (CI, 0.016 to 0.028) mL/mm Hg after fish oil ingestion (P<.05). No changes occurred in arterial blood pressure, cardiac output, stroke volume, or systemic vascular resistance with either intervention. The improved compliance estimates with fish oil ingestion occurred without altering fasting blood glucose and cholesterol concentrations. These results support the hypothesis that fish oils alter vascular reactivity and favorably influence arterial wall characteristics in patients with non-insulin-dependent diabetes mellitus. These direct vascular effects, expressed at the level of the vessel wall, may contribute to the cardioprotective actions of fish oil in humans.

Original languageEnglish (US)
Pages (from-to)1425-1429
Number of pages5
JournalArteriosclerosis, thrombosis, and vascular biology
Volume14
Issue number9
DOIs
StatePublished - Jan 1 1994

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Fish Oils
Type 2 Diabetes Mellitus
Compliance
Confidence Intervals
Blood Vessels
Arteries
Eating
Unsaturated Dietary Fats
Cardiac Output
Vascular Resistance
Stroke Volume
Pulse
Blood Glucose
Fasting
Arterial Pressure
Cholesterol
Placebos

Keywords

  • Compliance
  • Fish oil
  • Hemodynamics
  • Resistance

Cite this

Fish oil improves arterial compliance in non-insulin-dependent diabetes mellitus. / McVeigh, Gary E.; Brennan, Geraldine M.; Cohn, Jay N; Finkelstein, Stanley M; Hayes, Randal J.; Johnston, George D.

In: Arteriosclerosis, thrombosis, and vascular biology, Vol. 14, No. 9, 01.01.1994, p. 1425-1429.

Research output: Contribution to journalArticle

McVeigh, Gary E. ; Brennan, Geraldine M. ; Cohn, Jay N ; Finkelstein, Stanley M ; Hayes, Randal J. ; Johnston, George D. / Fish oil improves arterial compliance in non-insulin-dependent diabetes mellitus. In: Arteriosclerosis, thrombosis, and vascular biology. 1994 ; Vol. 14, No. 9. pp. 1425-1429.
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