First World Consensus Conference on pancreas transplantation: Part II – recommendations

Ugo Boggi, Fabio Vistoli, Axel Andres, Helmut P. Arbogast, Lionel Badet, Walter Baronti, Stephen T. Bartlett, Enrico Benedetti, Julien Branchereau, George W. Burke, Fanny Buron, Rossana Caldara, Massimo Cardillo, Daniel Casanova, Federica Cipriani, Matthew Cooper, Adamasco Cupisti, Josè Davide, Cinthia Drachenberg, Eelco J.P. de KoningGiuseppe Maria Ettorre, Laureano Fernandez Cruz, Jonathan A. Fridell, Peter J. Friend, Lucrezia Furian, Osama A. Gaber, Angelika C. Gruessner, Rainer W.G. Gruessner, Jenny E. Gunton, Duck Jong Han, Sara Iacopi, Emanuele Federico Kauffmann, Dixon Kaufman, Takashi Kenmochi, Hussein A. Khambalia, Quirino Lai, Robert M. Langer, Paola Maffi, Lorella Marselli, Francesco Menichetti, Mario Miccoli, Shruti Mittal, Emmanuel Morelon, Niccolò Napoli, Flavia Neri, Jose Oberholzer, Jon S. Odorico, Robert Öllinger, Gabriel Oniscu, Giuseppe Orlando, Monica Ortenzi, Marcelo Perosa, Vittorio Grazio Perrone, Henry Pleass, Robert R. Redfield, Claudio Ricci, Paolo Rigotti, R. Paul Robertson, Lainie F. Ross, Massimo Rossi, Frantisek Saudek, Joseph R. Scalea, Peter Schenker, Antonio Secchi, Carlo Socci, Donzilia Sousa Silva, Jean Paul Squifflet, Peter G. Stock, Robert J. Stratta, Chiara Terrenzio, Pablo Uva, Christopher J.E. Watson, Steven A. White, Piero Marchetti, Raja Kandaswamy, Thierry Berney

Research output: Contribution to journalArticlepeer-review

Abstract

The First World Consensus Conference on Pancreas Transplantation provided 49 jury deliberations regarding the impact of pancreas transplantation on the treatment of diabetic patients, and 110 experts’ recommendations for the practice of pancreas transplantation. The main message from this consensus conference is that both simultaneous pancreas-kidney transplantation (SPK) and pancreas transplantation alone can improve long-term patient survival, and all types of pancreas transplantation dramatically improve the quality of life of recipients. Pancreas transplantation may also improve the course of chronic complications of diabetes, depending on their severity. Therefore, the advantages of pancreas transplantation appear to clearly surpass potential disadvantages. Pancreas after kidney transplantation increases the risk of mortality only in the early period after transplantation, but is associated with improved life expectancy thereafter. Additionally, preemptive SPK, when compared to SPK performed in patients undergoing dialysis, appears to be associated with improved outcomes. Time on dialysis has negative prognostic implications in SPK recipients. Increased long-term survival, improvement in the course of diabetic complications, and amelioration of quality of life justify preferential allocation of kidney grafts to SPK recipients. Audience discussions and live voting are available online at the following URL address: http://mediaeventi.unipi.it/category/1st-world-consensus-conference-of-pancreas-transplantation/246.

Original languageEnglish (US)
Pages (from-to)17-59
Number of pages43
JournalAmerican Journal of Transplantation
Volume21 Suppl 3
Issue numberS3
Early online dateJul 10 2021
DOIs
StatePublished - Sep 2021

Bibliographical note

Funding Information:
This Consensus Conference is dedicated in the loved memory of Mr. Fabrizio Iacopini, who made most of the local arrangements for the live sessions and unexpectedly died due to COVID‐19 before these proceeding could be published. The first World Consensus Conference had no funding from commercial companies. The conference received a main unrestricted grant from Fondazione Pisa. The following Institutions also provided additional financial support: Regione Toscana, Università di Pisa, and Azienda Ospedaliero Universitaria Pisana.

Funding Information:
This Consensus Conference is dedicated in the loved memory of Mr. Fabrizio Iacopini, who made most of the local arrangements for the live sessions and unexpectedly died due to COVID-19 before these proceeding could be published. The first World Consensus Conference had no funding from commercial companies. The conference received a main unrestricted grant from Fondazione Pisa. The following Institutions also provided additional financial support: Regione Toscana, Universit? di Pisa, and Azienda Ospedaliero Universitaria Pisana.

Publisher Copyright:
© 2021 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons

Keywords

  • clinical research/practice
  • diabetes
  • pancreas/simultaneous pancreas-kidney transplantation
  • survey
  • Pancreas Transplantation
  • Humans
  • Quality of Life
  • Diabetes Mellitus, Type 1
  • Graft Survival
  • Kidney Transplantation
  • Renal Dialysis

PubMed: MeSH publication types

  • Research Support, Non-U.S. Gov't
  • Journal Article

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