First trimester phthalate exposure and male newborn genital anomalies

Sheela Sathyanarayana, Richard Grady, Emily S. Barrett, Bruce Redmon, Ruby H.N. Nguyen, Julia S. Barthold, Nicole R. Bush, Shanna H. Swan

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Background Anti-androgenic phthalates are environmental chemicals that affect male genital development in rodents leading to genitourinary birth defects. We examined whether first trimester phthalate exposure may exert similar effects in humans leading to an increased incidence of newborn male genital anomalies in a multi-center cohort study. Methods We recruited first trimester pregnant women within The Infant Development and the Environment Study (TIDES) from 2010 to 2012 from four study centers and limited analyses to all mother/male infant dyads who had complete urinary phthalate and birth exam data (N=371). We used multivariate logistic regression to determine the odds of having a genital anomaly in relation to phthalate exposure. Results Hydrocele was the primary abnormality observed in the cohort (N=30) followed by undescended testes (N=5) and hypospadias (N=3). We observed a statistically significant 2.5 fold increased risk (95% CI 1.1, 5.9) of having any anomaly and 3.0 fold increased risk (95% CI 1.2, 7.6) of isolated hydrocele in relation to a one log unit increase in the sum of di-ethylhexyl phthalate (DEHP) metabolites. Conclusions First trimester urinary DEHP metabolite concentrations were associated with increased odds of any newborn genital anomaly, and this association was primarily driven by isolated hydrocele which made up the majority of anomalies in newborn males. The association with hydrocele has not been previously reported and suggests that it may be an endpoint affected by prenatal phthalate exposures in the first trimester of development. Future human studies should include hydrocele assessment in order to confirm findings.

Original languageEnglish (US)
Pages (from-to)777-782
Number of pages6
JournalEnvironmental Research
StatePublished - Nov 1 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc.


  • Hydrocele
  • Hypospadias
  • Phthalate
  • Undescended testis


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