First total synthesis of (+)-vedelianin, a potent antiproliferative agent

Joseph J. Topczewski, David F. Wiemer

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The total synthesis of (+)-vedelianin has been accomplished in 18 steps from vanillin. Preparation of a key intermediate in nonracemic form through a Shi epoxidation has allowed determination of the absolute stereochemistry of the natural product as the (2S,3R,4aR,9aR)-isomer.

Original languageEnglish (US)
Pages (from-to)1628-1630
Number of pages3
JournalTetrahedron Letters
Issue number14
StatePublished - Apr 6 2011

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