First-pass metabolism of ethanol is negligible in rat gastric mucosa

Michael D. Levitt; Julie Furne; Eugene Demaster

doi:10.1111/j.1530-0277.1997.tb03763.x

First-pass metabolism of ethanol is negligible in rat gastric mucosa

Michael D. Levitt, Julie Furne, Eugene Demaster

Medicine - Veteran's Administration Medical Center

Research output: Contribution to journal › Article › peer-review

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Abstract

Controversy exists concerning whether first-pass metabolism of imbibed ethanol occurs in the gastric mucosa or liver. We assessed ethanol metabolism in rat gastric mucosa by determining to what extent intact [¹⁴C]ethanol in body water plus hepatic metabolism could account for [¹⁴C]ethanol absorbed from the pylorus-ligated stomach. Intact [¹⁴C]ethanol in systemic body water accounted for 84 ± 1.9% of the [¹⁴C]ethanol absorbed from the stomach over a 30-min period. Assuming a 15 ml/min hepatic blood flow, the predicted hepatic metabolism of [¹⁴C]ethanol over the 30 min of the study was 18% of the dose. The sum of intact [¹⁴C]ethanol and predicted hepatic metabolism accounted for 100% of the ethanol absorbed from the stomach. We conclude that negligible metabolism of ethanol occurred in the gastric mucosa.

Original language	English (US)
Pages (from-to)	293-297
Number of pages	5
Journal	Alcoholism: Clinical and Experimental Research
Volume	21
Issue number	2
DOIs	https://doi.org/10.1111/j.1530-0277.1997.tb03763.x
State	Published - 1997

Keywords

Alcohol Dehydrogenase
Ethanol
First-Pass Metabolism
Gastric Mucosa

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10.1111/j.1530-0277.1997.tb03763.x

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abstract = "Controversy exists concerning whether first-pass metabolism of imbibed ethanol occurs in the gastric mucosa or liver. We assessed ethanol metabolism in rat gastric mucosa by determining to what extent intact [14C]ethanol in body water plus hepatic metabolism could account for [14C]ethanol absorbed from the pylorus-ligated stomach. Intact [14C]ethanol in systemic body water accounted for 84 ± 1.9% of the [14C]ethanol absorbed from the stomach over a 30-min period. Assuming a 15 ml/min hepatic blood flow, the predicted hepatic metabolism of [14C]ethanol over the 30 min of the study was 18% of the dose. The sum of intact [14C]ethanol and predicted hepatic metabolism accounted for 100% of the ethanol absorbed from the stomach. We conclude that negligible metabolism of ethanol occurred in the gastric mucosa.",

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T1 - First-pass metabolism of ethanol is negligible in rat gastric mucosa

AU - Levitt, Michael D.

AU - Furne, Julie

AU - Demaster, Eugene

PY - 1997

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N2 - Controversy exists concerning whether first-pass metabolism of imbibed ethanol occurs in the gastric mucosa or liver. We assessed ethanol metabolism in rat gastric mucosa by determining to what extent intact [14C]ethanol in body water plus hepatic metabolism could account for [14C]ethanol absorbed from the pylorus-ligated stomach. Intact [14C]ethanol in systemic body water accounted for 84 ± 1.9% of the [14C]ethanol absorbed from the stomach over a 30-min period. Assuming a 15 ml/min hepatic blood flow, the predicted hepatic metabolism of [14C]ethanol over the 30 min of the study was 18% of the dose. The sum of intact [14C]ethanol and predicted hepatic metabolism accounted for 100% of the ethanol absorbed from the stomach. We conclude that negligible metabolism of ethanol occurred in the gastric mucosa.

AB - Controversy exists concerning whether first-pass metabolism of imbibed ethanol occurs in the gastric mucosa or liver. We assessed ethanol metabolism in rat gastric mucosa by determining to what extent intact [14C]ethanol in body water plus hepatic metabolism could account for [14C]ethanol absorbed from the pylorus-ligated stomach. Intact [14C]ethanol in systemic body water accounted for 84 ± 1.9% of the [14C]ethanol absorbed from the stomach over a 30-min period. Assuming a 15 ml/min hepatic blood flow, the predicted hepatic metabolism of [14C]ethanol over the 30 min of the study was 18% of the dose. The sum of intact [14C]ethanol and predicted hepatic metabolism accounted for 100% of the ethanol absorbed from the stomach. We conclude that negligible metabolism of ethanol occurred in the gastric mucosa.

KW - Alcohol Dehydrogenase

KW - Ethanol

KW - First-Pass Metabolism

KW - Gastric Mucosa

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First-pass metabolism of ethanol is negligible in rat gastric mucosa

Abstract

Keywords

UN SDGs

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