First-pass metabolism of ethanol is negligible in rat gastric mucosa

Michael D. Levitt, Julie Furne, Eugene Demaster

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Controversy exists concerning whether first-pass metabolism of imbibed ethanol occurs in the gastric mucosa or liver. We assessed ethanol metabolism in rat gastric mucosa by determining to what extent intact [14C]ethanol in body water plus hepatic metabolism could account for [14C]ethanol absorbed from the pylorus-ligated stomach. Intact [14C]ethanol in systemic body water accounted for 84 ± 1.9% of the [14C]ethanol absorbed from the stomach over a 30-min period. Assuming a 15 ml/min hepatic blood flow, the predicted hepatic metabolism of [14C]ethanol over the 30 min of the study was 18% of the dose. The sum of intact [14C]ethanol and predicted hepatic metabolism accounted for 100% of the ethanol absorbed from the stomach. We conclude that negligible metabolism of ethanol occurred in the gastric mucosa.

Original languageEnglish (US)
Pages (from-to)293-297
Number of pages5
JournalAlcoholism: Clinical and Experimental Research
Volume21
Issue number2
DOIs
StatePublished - 1997

Keywords

  • Alcohol Dehydrogenase
  • Ethanol
  • First-Pass Metabolism
  • Gastric Mucosa

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