First in-vivo human imaging at 10.5T: Imaging the body at 447 MHz

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate the feasibility of imaging the human torso and to evaluate the performance of several radiofrequency (RF) management strategies at 10.5T. Methods: Healthy volunteers were imaged on a 10.5T whole-body scanner in multiple target anatomies, including the prostate, hip, kidney, liver, and heart. Phase-only shimming and spoke pulses were used to demonstrate their performance in managing the B+ 1 inhomogeneity present at 447 MHz. Imaging protocols included both qualitative and quantitative acquisitions to show the feasibility of imaging with different contrasts. Results: High-quality images were acquired and demonstrated excellent overall contrast and signal-to-noise ratio. The experimental results matched well with predictions and suggested good translational capabilities of the RF management strategies previously developed at 7T. Phase-only shimming provided increased efficiency, but showed pronounced limitations in homogeneity, demonstrating the need for the increased degrees of freedom made possible through single- and multispoke RF pulse design. Conclusion: The first in-vivo human imaging was successfully performed at 10.5T using previously developed RF management strategies. Further improvement in RF coils, transmit chain, and full integration of parallel transmit functionality are needed to fully realize the benefits of 10.5T.

Original languageEnglish (US)
JournalMagnetic resonance in medicine
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Torso
Signal-To-Noise Ratio
Hip
Prostate
Anatomy
Healthy Volunteers
Kidney
Liver

Keywords

  • 10.5T
  • body imaging
  • magnetic resonance imaging
  • parallel transmit
  • ultra-high field imaging

PubMed: MeSH publication types

  • Journal Article

Cite this

@article{47da0393b3c74380bc510b8904e6cdf4,
title = "First in-vivo human imaging at 10.5T: Imaging the body at 447 MHz",
abstract = "Purpose: To investigate the feasibility of imaging the human torso and to evaluate the performance of several radiofrequency (RF) management strategies at 10.5T. Methods: Healthy volunteers were imaged on a 10.5T whole-body scanner in multiple target anatomies, including the prostate, hip, kidney, liver, and heart. Phase-only shimming and spoke pulses were used to demonstrate their performance in managing the B+ 1 inhomogeneity present at 447 MHz. Imaging protocols included both qualitative and quantitative acquisitions to show the feasibility of imaging with different contrasts. Results: High-quality images were acquired and demonstrated excellent overall contrast and signal-to-noise ratio. The experimental results matched well with predictions and suggested good translational capabilities of the RF management strategies previously developed at 7T. Phase-only shimming provided increased efficiency, but showed pronounced limitations in homogeneity, demonstrating the need for the increased degrees of freedom made possible through single- and multispoke RF pulse design. Conclusion: The first in-vivo human imaging was successfully performed at 10.5T using previously developed RF management strategies. Further improvement in RF coils, transmit chain, and full integration of parallel transmit functionality are needed to fully realize the benefits of 10.5T.",
keywords = "10.5T, body imaging, magnetic resonance imaging, parallel transmit, ultra-high field imaging",
author = "Xiaoxuan He and Ert{\"u}rk, {M. Arcan} and Andrea Grant and Xiaoping Wu and Lagore, {Russell L.} and Lance DelaBarre and Yiğitcan Eryaman and Gregor Adriany and Auerbach, {Eddie J.} and {Van de Moortele}, {Pierre Fran{\cc}ois} and K{\^a}mil Uğurbil and Metzger, {Gregory J.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/mrm.28131",
language = "English (US)",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - First in-vivo human imaging at 10.5T

T2 - Imaging the body at 447 MHz

AU - He, Xiaoxuan

AU - Ertürk, M. Arcan

AU - Grant, Andrea

AU - Wu, Xiaoping

AU - Lagore, Russell L.

AU - DelaBarre, Lance

AU - Eryaman, Yiğitcan

AU - Adriany, Gregor

AU - Auerbach, Eddie J.

AU - Van de Moortele, Pierre François

AU - Uğurbil, Kâmil

AU - Metzger, Gregory J.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: To investigate the feasibility of imaging the human torso and to evaluate the performance of several radiofrequency (RF) management strategies at 10.5T. Methods: Healthy volunteers were imaged on a 10.5T whole-body scanner in multiple target anatomies, including the prostate, hip, kidney, liver, and heart. Phase-only shimming and spoke pulses were used to demonstrate their performance in managing the B+ 1 inhomogeneity present at 447 MHz. Imaging protocols included both qualitative and quantitative acquisitions to show the feasibility of imaging with different contrasts. Results: High-quality images were acquired and demonstrated excellent overall contrast and signal-to-noise ratio. The experimental results matched well with predictions and suggested good translational capabilities of the RF management strategies previously developed at 7T. Phase-only shimming provided increased efficiency, but showed pronounced limitations in homogeneity, demonstrating the need for the increased degrees of freedom made possible through single- and multispoke RF pulse design. Conclusion: The first in-vivo human imaging was successfully performed at 10.5T using previously developed RF management strategies. Further improvement in RF coils, transmit chain, and full integration of parallel transmit functionality are needed to fully realize the benefits of 10.5T.

AB - Purpose: To investigate the feasibility of imaging the human torso and to evaluate the performance of several radiofrequency (RF) management strategies at 10.5T. Methods: Healthy volunteers were imaged on a 10.5T whole-body scanner in multiple target anatomies, including the prostate, hip, kidney, liver, and heart. Phase-only shimming and spoke pulses were used to demonstrate their performance in managing the B+ 1 inhomogeneity present at 447 MHz. Imaging protocols included both qualitative and quantitative acquisitions to show the feasibility of imaging with different contrasts. Results: High-quality images were acquired and demonstrated excellent overall contrast and signal-to-noise ratio. The experimental results matched well with predictions and suggested good translational capabilities of the RF management strategies previously developed at 7T. Phase-only shimming provided increased efficiency, but showed pronounced limitations in homogeneity, demonstrating the need for the increased degrees of freedom made possible through single- and multispoke RF pulse design. Conclusion: The first in-vivo human imaging was successfully performed at 10.5T using previously developed RF management strategies. Further improvement in RF coils, transmit chain, and full integration of parallel transmit functionality are needed to fully realize the benefits of 10.5T.

KW - 10.5T

KW - body imaging

KW - magnetic resonance imaging

KW - parallel transmit

KW - ultra-high field imaging

UR - http://www.scopus.com/inward/record.url?scp=85076734144&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076734144&partnerID=8YFLogxK

U2 - 10.1002/mrm.28131

DO - 10.1002/mrm.28131

M3 - Article

C2 - 31846121

AN - SCOPUS:85076734144

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

ER -