First finding of genetic and antigenic diversity in 1b-BVDV isolates from Argentina

A. Pecora; D. A. Malacari; J. F. Ridpath; M. S. Perez Aguirreburualde; G. Combessies; A. C. Odeón; S. A. Romera; M. D. Golemba; A. Wigdorovitz

doi:10.1016/j.rvsc.2013.11.004

First finding of genetic and antigenic diversity in 1b-BVDV isolates from Argentina

A. Pecora, D. A. Malacari, J. F. Ridpath, M. S. Perez Aguirreburualde, G. Combessies, A. C. Odeón, S. A. Romera, M. D. Golemba, A. Wigdorovitz

Veterinary Population Medicine

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Infection with Bovine Viral Diarrhea Viruses (BVDV) in cattle results in a wide range of clinical manifestations, ranging from mild respiratory disease to fetal death and mucosal disease, depending on the virulence of the virus and the immune and reproductive status of the host. In this study 30 Argentinean BVDV isolates were characterized by phylogenetic analysis. The isolates were genotyped based on comparison of the 5' untranslated region (5' UTR) and the E2 gene. In both phylogenetic trees, 76% of the viruses were assigned to BVDV 1b, whereas BVDV 1a, 2a and 2b were also found. Eight of the BVDV 1b isolates were further characterized by cross-neutralization tests using guinea pig antisera and sera from bovines vaccinated with two different commercial vaccines. The results demonstrated the presence of a marked antigenic diversity among Argentinean BVDV isolates and suggest the need to incorporate BVDV 1b isolates in diagnostic strategies.

Original language	English (US)
Pages (from-to)	204-212
Number of pages	9
Journal	Research in veterinary science
Volume	96
Issue number	1
DOIs	https://doi.org/10.1016/j.rvsc.2013.11.004
State	Published - Feb 2014

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Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

Antigenic diversity
Bovine Viral Diarrhea Virus
Cattle viruses
Pestivirus
Phylogenetic analysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Infection with Bovine Viral Diarrhea Viruses (BVDV) in cattle results in a wide range of clinical manifestations, ranging from mild respiratory disease to fetal death and mucosal disease, depending on the virulence of the virus and the immune and reproductive status of the host. In this study 30 Argentinean BVDV isolates were characterized by phylogenetic analysis. The isolates were genotyped based on comparison of the 5' untranslated region (5' UTR) and the E2 gene. In both phylogenetic trees, 76% of the viruses were assigned to BVDV 1b, whereas BVDV 1a, 2a and 2b were also found. Eight of the BVDV 1b isolates were further characterized by cross-neutralization tests using guinea pig antisera and sera from bovines vaccinated with two different commercial vaccines. The results demonstrated the presence of a marked antigenic diversity among Argentinean BVDV isolates and suggest the need to incorporate BVDV 1b isolates in diagnostic strategies.",

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AU - Malacari, D. A.

AU - Ridpath, J. F.

AU - Perez Aguirreburualde, M. S.

AU - Combessies, G.

AU - Odeón, A. C.

AU - Romera, S. A.

AU - Golemba, M. D.

AU - Wigdorovitz, A.

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N2 - Infection with Bovine Viral Diarrhea Viruses (BVDV) in cattle results in a wide range of clinical manifestations, ranging from mild respiratory disease to fetal death and mucosal disease, depending on the virulence of the virus and the immune and reproductive status of the host. In this study 30 Argentinean BVDV isolates were characterized by phylogenetic analysis. The isolates were genotyped based on comparison of the 5' untranslated region (5' UTR) and the E2 gene. In both phylogenetic trees, 76% of the viruses were assigned to BVDV 1b, whereas BVDV 1a, 2a and 2b were also found. Eight of the BVDV 1b isolates were further characterized by cross-neutralization tests using guinea pig antisera and sera from bovines vaccinated with two different commercial vaccines. The results demonstrated the presence of a marked antigenic diversity among Argentinean BVDV isolates and suggest the need to incorporate BVDV 1b isolates in diagnostic strategies.

AB - Infection with Bovine Viral Diarrhea Viruses (BVDV) in cattle results in a wide range of clinical manifestations, ranging from mild respiratory disease to fetal death and mucosal disease, depending on the virulence of the virus and the immune and reproductive status of the host. In this study 30 Argentinean BVDV isolates were characterized by phylogenetic analysis. The isolates were genotyped based on comparison of the 5' untranslated region (5' UTR) and the E2 gene. In both phylogenetic trees, 76% of the viruses were assigned to BVDV 1b, whereas BVDV 1a, 2a and 2b were also found. Eight of the BVDV 1b isolates were further characterized by cross-neutralization tests using guinea pig antisera and sera from bovines vaccinated with two different commercial vaccines. The results demonstrated the presence of a marked antigenic diversity among Argentinean BVDV isolates and suggest the need to incorporate BVDV 1b isolates in diagnostic strategies.

KW - Antigenic diversity

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KW - Cattle viruses

KW - Pestivirus

KW - Phylogenetic analysis

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First finding of genetic and antigenic diversity in 1b-BVDV isolates from Argentina

Abstract

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Keywords

UN SDGs

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