The purpose of this study was to determine whether maternal urinary phthalate metabolite concentrations are associated with the development of higher blood pressure or pregnancy-induced hypertension (PIH). Participants were women without chronic hypertension who enrolled in The Infant Development and the Environment Study, a prospective pregnancy cohort conducted at four U.S. academic medical centers from 2010–2012. Prenatal records were reviewed to obtain blood pressure measurements and diagnoses of PIH (gestational hypertension, preeclampsia, eclampsia, and HELLP syndrome, defined as hemolysis, elevated liver enzymes, and low platelet count). Complete-case analyses used multivariable linear and logistic regression for analysis of blood pressure measurements and PIH diagnoses, respectively. In the final dataset (N = 668), higher concentrations of first-trimester monoethyl phthalate (MEP) and mono-3-carboxypropyl phthalate (MCPP) and third-trimester mono-isobutyl phthalate (MiBP) were significantly associated with a medical chart diagnosis of PIH. First-trimester mono-n-butyl phthalate (MBP) and MEP along with the sum of di(2-ethylhexyl) phthalate metabolites (∑DEHP) were each associated with increased systolic blood pressure across pregnancy. In conclusion, several phthalate metabolite concentrations were significantly associated with PIH and greater increases in systolic blood pressure across pregnancy.
|Original language||English (US)|
|Journal||International journal of environmental research and public health|
|State||Published - Oct 2 2021|
Bibliographical noteFunding Information:
Funding: This study was funded in part by the National Institute of Environmental Health Sciences (R01 ES016863-02S4, R01 ES016863-04, and P30 ES005022) and the Intramural Research Program of the National Institute of Environmental Health Sciences (ZIA ES103313).
Acknowledgments: This study was funded in part by the Intramural Research Program of the National Institute of Environmental Health Sciences, the National Institutes of Health. Results from this study were presented at the 10th International Symposium on Diabetes, Hypertension, Metabolic Syndrome and Pregnancy located in Florence, Italy, 29 May–1 June 2019.
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- Blood pressure
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, N.I.H., Intramural