Finite element analysis of hollow HfO2 microneedles for transdermal drug delivery

Yong Hua Zhang, Yinghong Tian, Stephen A Campbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Microneedles are an important tool for promoting transdermal drug delivery, especially for macromolecular drugs. In this paper, the fabrication method of hollow hafnium oxide (HfO2) microneedles mainly based on deep reactive ion etching of silicon and atomic layer deposition of HfO2, and the finite element analysis of the microneedles based on ANSYS software are presented. The fabrication process is simplified by using only one mask. The finite element analysis of a single microneedle shows that the flexibility of the microneedles can be easily adjusted for various applications. The finite element analysis of a 3×3 HfO2 microneedle array applied on the skin explains the 'bed of nail' effect nicely, i.e., the skin is not liable to be pierced when the density of microneedles in array increases. The presented research work here provides useful information for design optimization of HfO2 microneedles.

Original languageEnglish (US)
Title of host publicationProceedings - 2017 10th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2017
EditorsSong Qiu, Hongying Liu, Li Sun, Lipo Wang, Qingli Li, Mei Zhou
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1-6
Number of pages6
ISBN (Electronic)9781538619377
DOIs
StatePublished - Feb 22 2018
Event10th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2017 - Shanghai, China
Duration: Oct 14 2017Oct 16 2017

Publication series

NameProceedings - 2017 10th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2017
Volume2018-January

Other

Other10th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2017
CountryChina
CityShanghai
Period10/14/1710/16/17

Fingerprint

Finite Element Analysis
Drug delivery
Finite element method
Skin
Hafnium oxides
Pharmaceutical Preparations
Fabrication
Nails
Atomic layer deposition
Reactive ion etching
Silicon
Masks
Software
Ions
Research

Keywords

  • Finite element analysis
  • HfO
  • atomic layer deposition
  • bed of nail effect
  • micro-electro-mechanical systems
  • microneedle
  • transdermal drug delivery

Cite this

Zhang, Y. H., Tian, Y., & Campbell, S. A. (2018). Finite element analysis of hollow HfO2 microneedles for transdermal drug delivery. In S. Qiu, H. Liu, L. Sun, L. Wang, Q. Li, & M. Zhou (Eds.), Proceedings - 2017 10th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2017 (pp. 1-6). (Proceedings - 2017 10th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2017; Vol. 2018-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CISP-BMEI.2017.8302245

Finite element analysis of hollow HfO2 microneedles for transdermal drug delivery. / Zhang, Yong Hua; Tian, Yinghong; Campbell, Stephen A.

Proceedings - 2017 10th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2017. ed. / Song Qiu; Hongying Liu; Li Sun; Lipo Wang; Qingli Li; Mei Zhou. Institute of Electrical and Electronics Engineers Inc., 2018. p. 1-6 (Proceedings - 2017 10th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2017; Vol. 2018-January).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zhang, YH, Tian, Y & Campbell, SA 2018, Finite element analysis of hollow HfO2 microneedles for transdermal drug delivery. in S Qiu, H Liu, L Sun, L Wang, Q Li & M Zhou (eds), Proceedings - 2017 10th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2017. Proceedings - 2017 10th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2017, vol. 2018-January, Institute of Electrical and Electronics Engineers Inc., pp. 1-6, 10th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2017, Shanghai, China, 10/14/17. https://doi.org/10.1109/CISP-BMEI.2017.8302245
Zhang YH, Tian Y, Campbell SA. Finite element analysis of hollow HfO2 microneedles for transdermal drug delivery. In Qiu S, Liu H, Sun L, Wang L, Li Q, Zhou M, editors, Proceedings - 2017 10th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2017. Institute of Electrical and Electronics Engineers Inc. 2018. p. 1-6. (Proceedings - 2017 10th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2017). https://doi.org/10.1109/CISP-BMEI.2017.8302245
Zhang, Yong Hua ; Tian, Yinghong ; Campbell, Stephen A. / Finite element analysis of hollow HfO2 microneedles for transdermal drug delivery. Proceedings - 2017 10th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2017. editor / Song Qiu ; Hongying Liu ; Li Sun ; Lipo Wang ; Qingli Li ; Mei Zhou. Institute of Electrical and Electronics Engineers Inc., 2018. pp. 1-6 (Proceedings - 2017 10th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2017).
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