Fine-needle aspiration cytology of pancreatic somatostatinoma: The importance of immunohistochemistry for the cytologic diagnosis of pancreatic endocrine neoplasms

Edward B. Stelow, Carolyn Woon, Stefan E. Pambuccian, Michael Thrall, Michael W. Stanley, Rebecca Lai, James S Mallery, H. Evin Gulbahce

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Pancreatic somatostatinoma is a rare pancreatic endocrine neoplasm representing as little as 1% of pancreatic endocrine neoplasms (PENs). The histologic features of this tumor are like those of other PENs. except that it commonly forms acinar structures and often has cells with abundant, granular cytoplasm. We have recently encountered two of these neoplasms sampled by endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA). We discuss the cytologic and immunohistochemical findings of these two cases and the cytologie similarities these neoplasms share with pancreatic acinar-cell carcinoma (PACC). We review the cytologic features of PEN and PACC and discuss the importance of cell block irnmunohistochemistry in the diagnosis of pancreatic neoplasia sampled by EUS-guided FNA.

Original languageEnglish (US)
Pages (from-to)100-105
Number of pages6
JournalDiagnostic Cytopathology
Volume33
Issue number2
DOIs
StatePublished - Aug 1 2005

Keywords

  • Acinar-cell carcinoma
  • Cytology
  • Endoscopic ultrasound
  • Fine-needle aspiration
  • Immunohistochemistry
  • Islet cell tumor
  • Pancreas
  • Pancreatic endocrine neoplasm
  • Somatostatinoma

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