Finding better protein engineering strategies

Romas J. Kazlauskas; Uwe T. Bornscheuer

doi:10.1038/nchembio0809-526

Finding better protein engineering strategies

Romas J. Kazlauskas
, Uwe T. Bornscheuer

Synthetic Biology and Biotechnology Division

Research output: Contribution to journal › Comment/debate › peer-review

202 Scopus citations

Abstract

Protein improvement strategies today involve widely varying combinations of rational design with random mutagenesis and screening. To make further progress-defined as making subsequent protein engineering problems easier to solve-protein engineers must critically compare these strategies and eliminate less effective ones.

Original language	English (US)
Pages (from-to)	526-529
Number of pages	4
Journal	Nature Chemical Biology
Volume	5
Issue number	8
DOIs	https://doi.org/10.1038/nchembio0809-526
State	Published - Aug 2009

Bibliographical note

Funding Information:
U.T.B. thanks the German Research Foundation (DFG, Grant Bo1862/4-1) and R.J.K. the US National Science Foundation (CHE-0616560) for financial support.

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title = "Finding better protein engineering strategies",

abstract = "Protein improvement strategies today involve widely varying combinations of rational design with random mutagenesis and screening. To make further progress-defined as making subsequent protein engineering problems easier to solve-protein engineers must critically compare these strategies and eliminate less effective ones.",

author = "Kazlauskas, \{Romas J.\} and Bornscheuer, \{Uwe T.\}",

note = "Funding Information: U.T.B. thanks the German Research Foundation (DFG, Grant Bo1862/4-1) and R.J.K. the US National Science Foundation (CHE-0616560) for financial support.",

year = "2009",

month = aug,

doi = "10.1038/nchembio0809-526",

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AU - Bornscheuer, Uwe T.

N1 - Funding Information: U.T.B. thanks the German Research Foundation (DFG, Grant Bo1862/4-1) and R.J.K. the US National Science Foundation (CHE-0616560) for financial support.

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N2 - Protein improvement strategies today involve widely varying combinations of rational design with random mutagenesis and screening. To make further progress-defined as making subsequent protein engineering problems easier to solve-protein engineers must critically compare these strategies and eliminate less effective ones.

AB - Protein improvement strategies today involve widely varying combinations of rational design with random mutagenesis and screening. To make further progress-defined as making subsequent protein engineering problems easier to solve-protein engineers must critically compare these strategies and eliminate less effective ones.

UR - https://www.scopus.com/pages/publications/68049111471

UR - https://www.scopus.com/pages/publications/68049111471#tab=citedBy

U2 - 10.1038/nchembio0809-526

DO - 10.1038/nchembio0809-526

M3 - Comment/debate

C2 - 19620988

AN - SCOPUS:68049111471

SN - 1552-4450

VL - 5

SP - 526

EP - 529

JO - Nature Chemical Biology

JF - Nature Chemical Biology

IS - 8

ER -

Finding better protein engineering strategies

Abstract

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