Abstract
Protein improvement strategies today involve widely varying combinations of rational design with random mutagenesis and screening. To make further progress-defined as making subsequent protein engineering problems easier to solve-protein engineers must critically compare these strategies and eliminate less effective ones.
Original language | English (US) |
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Pages (from-to) | 526-529 |
Number of pages | 4 |
Journal | Nature Chemical Biology |
Volume | 5 |
Issue number | 8 |
DOIs |
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State | Published - Aug 2009 |
Bibliographical note
Funding Information:U.T.B. thanks the German Research Foundation (DFG, Grant Bo1862/4-1) and R.J.K. the US National Science Foundation (CHE-0616560) for financial support.