Finding better protein engineering strategies

Romas J. Kazlauskas, Uwe T. Bornscheuer

Research output: Contribution to journalComment/debatepeer-review

189 Scopus citations


Protein improvement strategies today involve widely varying combinations of rational design with random mutagenesis and screening. To make further progress-defined as making subsequent protein engineering problems easier to solve-protein engineers must critically compare these strategies and eliminate less effective ones.

Original languageEnglish (US)
Pages (from-to)526-529
Number of pages4
JournalNature Chemical Biology
Issue number8
StatePublished - Aug 2009

Bibliographical note

Funding Information:
U.T.B. thanks the German Research Foundation (DFG, Grant Bo1862/4-1) and R.J.K. the US National Science Foundation (CHE-0616560) for financial support.


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