Fim operon variation in the emergence of Enterohemorrhagic Escherichia coli: An evolutionary and functional analysis

Nurmohammad Shaikh; Nicholas J. Holt; James R. Johnson; Phillip I. Tarr

doi:10.1111/j.1574-6968.2007.00781.x

Fim operon variation in the emergence of Enterohemorrhagic Escherichia coli: An evolutionary and functional analysis

Nurmohammad Shaikh, Nicholas J. Holt, James R. Johnson, Phillip I. Tarr

Medicine - Veteran's Administration Medical Center

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Fim operons were examined to illuminate the emergence of Escherichia coli O157:H7 from the less-virulent E. coli O55:H7. A fim invertible element deletion occurred only after O157:H7 descended from O55:H7, and after sorbitol nonfermenting O157 diverged. Type 1 pili nonexpression correlates with this deletion in all enterohemorrhagic E. coli (EHEC) tested. An N135K FimH mutation in the two most evolved O157:H7 clusters is not found in other EHEC. These data refine the evolutionary history of an emerging pathogen.

Original language	English (US)
Pages (from-to)	58-63
Number of pages	6
Journal	FEMS Microbiology Letters
Volume	273
Issue number	1
DOIs	https://doi.org/10.1111/j.1574-6968.2007.00781.x
State	Published - Aug 2007

Keywords

Evolution
FimH
Pili

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10.1111/j.1574-6968.2007.00781.x

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AU - Holt, Nicholas J.

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AU - Tarr, Phillip I.

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AB - Fim operons were examined to illuminate the emergence of Escherichia coli O157:H7 from the less-virulent E. coli O55:H7. A fim invertible element deletion occurred only after O157:H7 descended from O55:H7, and after sorbitol nonfermenting O157 diverged. Type 1 pili nonexpression correlates with this deletion in all enterohemorrhagic E. coli (EHEC) tested. An N135K FimH mutation in the two most evolved O157:H7 clusters is not found in other EHEC. These data refine the evolutionary history of an emerging pathogen.

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Fim operon variation in the emergence of Enterohemorrhagic Escherichia coli: An evolutionary and functional analysis

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