Filling in the Gaps in Metformin Biodegradation: a New Enzyme and a Metabolic Pathway for Guanylurea

Keyphrases

• Allophanate 5%
• Ammonia 11%
• Aquatic Life 5%
• Biodegradation 100%
• Bioinformatic Identification 5%
• Biuret 5%
• Carbon Dioxide 5%
• Cell Yield 5%
• Contaminants of Emerging Concern 5%
• COVID-19 Patients 5%
• Degradation Gene 5%
• Evolutionary Origin 5%
• Genomic Regions 5%
• Guanidine 16%
• Guanylurea 100%
• Homologous Enzymes 5%
• Hydrolases 33%
• Isochorismatase 5%
• Limiting Concentration 5%
• Metabolic Pathway 100%
• Metabolic Transformation 5%
• Metabolism 16%
• Metagenomic Next-generation Sequencing (mNGS) 5%
• Metformin 100%
• Municipal Wastewater Treatment Plant 5%
• Nitrogen Atom 5%
• Nitrogen Source 11%
• Non-target 5%
• Pairwise Alignment 5%
• Plant Microbiome 5%
• Potential Gains 5%
• Protein Family 5%
• Pseudomonas Mendocina 11%
• Relevant Genes 5%
• Sequence Similarity Network 5%
• Substrate Specificity 5%
• Treated Water 5%
• Triuret 5%
• Type 2 Diabetes Mellitus (T2DM) 5%
• Wastewater 5%
• Wastewater Treatment Plant 16%
• Water Pollutants 5%

Biochemistry, Genetics and Molecular Biology

• Biodegradation 100%
• Enzyme 100%
• Enzyme Specificity 14%
• Hydrolase 85%
• Metabolic Pathway 100%
• Metabolite 28%
• Metagenomics 14%
• Microbiome 14%
• Protein Family 14%
• Pseudomonas mendocina 28%
• Surface Property 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Ammonium 33%
• Biuret 16%
• Carbon Dioxide 16%
• Guanidine 50%
• Hydrolase 100%
• Metformin 100%
• Microbiome 16%
• Nitrogen 33%
• Non Insulin Dependent Diabetes Mellitus 16%
• Pseudomonas mendocina 33%
• Substrate Specificity 16%