Fibroblast traction-migration relationships in collagen gels

David I. Shreiber; Robert T. Tranquillo

Fibroblast traction-migration relationships in collagen gels

Biomedical Engineering

Research output: Contribution to journal › Conference article › peer-review

Abstract

We used our novel assay of cell behavior in tissue equivalents to continue investigating relationships between fibroblast traction and migration in collagen gels. The inhibition of HFF adhesion to collagen via an antibody targeted against the β1 integrin subunit significantly decreased cell traction and increased cell migration in free floating collagen. This stands in contrast to previous results where PDGF-BB induced an increase in RDF migration in free floating collagen that correlated with an increase in cell traction. These results demonstrate the complex response of fibroblasts to environmental cues, and point to opportunities to orchestrate cell behavior to affect the outcome of wound healing.

Original language	English (US)
Pages (from-to)	667-668
Number of pages	2
Journal	American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Volume	50
State	Published - Dec 1 2001
Event	Proceedings of the 2001 Bioengineering Conference - Snowbird, UT, United States Duration: Jun 27 2001 → Jul 1 2001

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title = "Fibroblast traction-migration relationships in collagen gels",

abstract = "We used our novel assay of cell behavior in tissue equivalents to continue investigating relationships between fibroblast traction and migration in collagen gels. The inhibition of HFF adhesion to collagen via an antibody targeted against the β1 integrin subunit significantly decreased cell traction and increased cell migration in free floating collagen. This stands in contrast to previous results where PDGF-BB induced an increase in RDF migration in free floating collagen that correlated with an increase in cell traction. These results demonstrate the complex response of fibroblasts to environmental cues, and point to opportunities to orchestrate cell behavior to affect the outcome of wound healing.",

author = "Shreiber, {David I.} and Tranquillo, {Robert T.}",

year = "2001",

month = dec,

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language = "English (US)",

volume = "50",

pages = "667--668",

journal = "American Society of Mechanical Engineers, Bioengineering Division (Publication) BED",

issn = "1071-6947",

note = "Proceedings of the 2001 Bioengineering Conference ; Conference date: 27-06-2001 Through 01-07-2001",

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T1 - Fibroblast traction-migration relationships in collagen gels

AU - Shreiber, David I.

AU - Tranquillo, Robert T.

PY - 2001/12/1

Y1 - 2001/12/1

N2 - We used our novel assay of cell behavior in tissue equivalents to continue investigating relationships between fibroblast traction and migration in collagen gels. The inhibition of HFF adhesion to collagen via an antibody targeted against the β1 integrin subunit significantly decreased cell traction and increased cell migration in free floating collagen. This stands in contrast to previous results where PDGF-BB induced an increase in RDF migration in free floating collagen that correlated with an increase in cell traction. These results demonstrate the complex response of fibroblasts to environmental cues, and point to opportunities to orchestrate cell behavior to affect the outcome of wound healing.

AB - We used our novel assay of cell behavior in tissue equivalents to continue investigating relationships between fibroblast traction and migration in collagen gels. The inhibition of HFF adhesion to collagen via an antibody targeted against the β1 integrin subunit significantly decreased cell traction and increased cell migration in free floating collagen. This stands in contrast to previous results where PDGF-BB induced an increase in RDF migration in free floating collagen that correlated with an increase in cell traction. These results demonstrate the complex response of fibroblasts to environmental cues, and point to opportunities to orchestrate cell behavior to affect the outcome of wound healing.

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M3 - Conference article

AN - SCOPUS:0242525091

SN - 1071-6947

VL - 50

SP - 667

EP - 668

JO - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

JF - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

T2 - Proceedings of the 2001 Bioengineering Conference

Y2 - 27 June 2001 through 1 July 2001

ER -

Fibroblast traction-migration relationships in collagen gels

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