Fetal rat lung phosphatidylcholine synthesis in diabetic and normal pregnancies. A comparison of prenatal dexamethasone treatments

Michael Y Tsai, Mark W. Josephson, David M. Brown

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The effects of maternal diabetes upon fetal lung surfactant phospholipid metabolism were studied using 19-day gestational age fetal rats from mothers with streptozotocin-induced diabetes mellitus. In this experimental animal model, maternal glucose intolerance significantly impaired fetal body and lung development. However, incorporation of [14C]palmitate and [3H]choline into lung total and disaturated phosphatidylcholine was unimpaired in offspring of diabetic mothers. Dexamethasone, which is known to promote fetal lung maturation in normal pregnancies, was administered to diabetic and control mothers during late gestation. Prenatal dexamethasone inhibited lung growth in both diabetic and control pregnancies. While this agent slightly stimulated [14C]palmitate incorporation into total phosphatidylcholine and markedly enhanced [3H]choline incorporation into both disaturated and total phosphatidylcholine in control pregnancies, it failed to stimulate incorporation of either precursor into fetal lung from diabetic pregnancies.

Original languageEnglish (US)
Pages (from-to)174-181
Number of pages8
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume664
Issue number1
DOIs
StatePublished - Apr 23 1981

Fingerprint

Pregnancy in Diabetics
Phosphatidylcholines
Dexamethasone
Rats
Palmitates
Medical problems
Choline
Lung
Pregnancy
Streptozocin
Metabolism
Surface-Active Agents
Phospholipids
Animals
Mothers
Glucose
Glucose Intolerance
Experimental Diabetes Mellitus
Gestational Age
Diabetes Mellitus

Keywords

  • (Fetal lung)
  • Development
  • Dexamethasone treatment
  • Diabetes
  • Maternal diabetes
  • Phosphatidylcholine synthesis
  • Streptozotocin

Cite this

@article{55e8a70adf2c4a15a36ef31a6cad6c39,
title = "Fetal rat lung phosphatidylcholine synthesis in diabetic and normal pregnancies. A comparison of prenatal dexamethasone treatments",
abstract = "The effects of maternal diabetes upon fetal lung surfactant phospholipid metabolism were studied using 19-day gestational age fetal rats from mothers with streptozotocin-induced diabetes mellitus. In this experimental animal model, maternal glucose intolerance significantly impaired fetal body and lung development. However, incorporation of [14C]palmitate and [3H]choline into lung total and disaturated phosphatidylcholine was unimpaired in offspring of diabetic mothers. Dexamethasone, which is known to promote fetal lung maturation in normal pregnancies, was administered to diabetic and control mothers during late gestation. Prenatal dexamethasone inhibited lung growth in both diabetic and control pregnancies. While this agent slightly stimulated [14C]palmitate incorporation into total phosphatidylcholine and markedly enhanced [3H]choline incorporation into both disaturated and total phosphatidylcholine in control pregnancies, it failed to stimulate incorporation of either precursor into fetal lung from diabetic pregnancies.",
keywords = "(Fetal lung), Development, Dexamethasone treatment, Diabetes, Maternal diabetes, Phosphatidylcholine synthesis, Streptozotocin",
author = "Tsai, {Michael Y} and Josephson, {Mark W.} and Brown, {David M.}",
year = "1981",
month = "4",
day = "23",
doi = "10.1016/0005-2760(81)90039-4",
language = "English (US)",
volume = "664",
pages = "174--181",
journal = "Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids",
issn = "1388-1981",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Fetal rat lung phosphatidylcholine synthesis in diabetic and normal pregnancies. A comparison of prenatal dexamethasone treatments

AU - Tsai, Michael Y

AU - Josephson, Mark W.

AU - Brown, David M.

PY - 1981/4/23

Y1 - 1981/4/23

N2 - The effects of maternal diabetes upon fetal lung surfactant phospholipid metabolism were studied using 19-day gestational age fetal rats from mothers with streptozotocin-induced diabetes mellitus. In this experimental animal model, maternal glucose intolerance significantly impaired fetal body and lung development. However, incorporation of [14C]palmitate and [3H]choline into lung total and disaturated phosphatidylcholine was unimpaired in offspring of diabetic mothers. Dexamethasone, which is known to promote fetal lung maturation in normal pregnancies, was administered to diabetic and control mothers during late gestation. Prenatal dexamethasone inhibited lung growth in both diabetic and control pregnancies. While this agent slightly stimulated [14C]palmitate incorporation into total phosphatidylcholine and markedly enhanced [3H]choline incorporation into both disaturated and total phosphatidylcholine in control pregnancies, it failed to stimulate incorporation of either precursor into fetal lung from diabetic pregnancies.

AB - The effects of maternal diabetes upon fetal lung surfactant phospholipid metabolism were studied using 19-day gestational age fetal rats from mothers with streptozotocin-induced diabetes mellitus. In this experimental animal model, maternal glucose intolerance significantly impaired fetal body and lung development. However, incorporation of [14C]palmitate and [3H]choline into lung total and disaturated phosphatidylcholine was unimpaired in offspring of diabetic mothers. Dexamethasone, which is known to promote fetal lung maturation in normal pregnancies, was administered to diabetic and control mothers during late gestation. Prenatal dexamethasone inhibited lung growth in both diabetic and control pregnancies. While this agent slightly stimulated [14C]palmitate incorporation into total phosphatidylcholine and markedly enhanced [3H]choline incorporation into both disaturated and total phosphatidylcholine in control pregnancies, it failed to stimulate incorporation of either precursor into fetal lung from diabetic pregnancies.

KW - (Fetal lung)

KW - Development

KW - Dexamethasone treatment

KW - Diabetes

KW - Maternal diabetes

KW - Phosphatidylcholine synthesis

KW - Streptozotocin

UR - http://www.scopus.com/inward/record.url?scp=0019826272&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019826272&partnerID=8YFLogxK

U2 - 10.1016/0005-2760(81)90039-4

DO - 10.1016/0005-2760(81)90039-4

M3 - Article

C2 - 6909030

AN - SCOPUS:0019826272

VL - 664

SP - 174

EP - 181

JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

SN - 1388-1981

IS - 1

ER -