Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate

Kristina M. Adams Waldorf; Jennifer E. Stencel-Baerenwald; Raj P. Kapur; Colin Studholme; Erica Boldenow; Jay Vornhagen; Audrey Baldessari; Manjiri K. Dighe; Jeff Thiel; Sean Merillat; Blair Armistead; Jennifer Tisoncik-Go; Richard R. Green; Michael A. Davis; Elyse C. Dewey; Marian R. Fairgrieve; J. Christopher Gatenby; Todd Richards; Gwenn A. Garden; Michael S. Diamond; Sandra E. Juul; Richard F. Grant; Larene Kuller; Dennis W.W. Shaw; Jason Ogle; G. Michael Gough; Wonsok Lee; Chris English; Robert F. Hevner; William B. Dobyns; Michael Gale; Lakshmi Rajagopal

doi:10.1038/nm.4193

Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate

Kristina M. Adams Waldorf, Jennifer E. Stencel-Baerenwald, Raj P. Kapur, Colin Studholme, Erica Boldenow, Jay Vornhagen, Audrey Baldessari, Manjiri K. Dighe, Jeff Thiel, Sean Merillat, Blair Armistead, Jennifer Tisoncik-Go, Richard R. Green, Michael A. Davis, Elyse C. Dewey, Marian R. Fairgrieve, J. Christopher Gatenby, Todd Richards, Gwenn A. Garden, Michael S. DiamondSandra E. Juul, Richard F. Grant, Larene Kuller, Dennis W.W. Shaw, Jason Ogle, G. Michael Gough, Wonsok Lee, Chris English, Robert F. Hevner, William B. Dobyns, Michael Gale, Lakshmi Rajagopal

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Abstract

We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.

Original language	English (US)
Pages (from-to)	1256-1259
Number of pages	4
Journal	Nature Medicine
Volume	22
Issue number	11
DOIs	https://doi.org/10.1038/nm.4193
State	Published - Nov 1 2016
Externally published	Yes

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© 2016 Nature America, Inc., part of Springer Nature. All rights reserved.

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Adams Waldorf, K. M., Stencel-Baerenwald, J. E., Kapur, R. P., Studholme, C., Boldenow, E., Vornhagen, J., Baldessari, A., Dighe, M. K., Thiel, J., Merillat, S., Armistead, B., Tisoncik-Go, J., Green, R. R., Davis, M. A., Dewey, E. C., Fairgrieve, M. R., Gatenby, J. C., Richards, T., Garden, G. A., ... Rajagopal, L. (2016). Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate. Nature Medicine, 22(11), 1256-1259. https://doi.org/10.1038/nm.4193

Adams Waldorf, KM, Stencel-Baerenwald, JE, Kapur, RP, Studholme, C, Boldenow, E, Vornhagen, J, Baldessari, A, Dighe, MK, Thiel, J, Merillat, S, Armistead, B, Tisoncik-Go, J, Green, RR, Davis, MA, Dewey, EC, Fairgrieve, MR, Gatenby, JC, Richards, T, Garden, GA, Diamond, MS, Juul, SE, Grant, RF, Kuller, L, Shaw, DWW, Ogle, J, Gough, GM, Lee, W, English, C, Hevner, RF, Dobyns, WB, Gale, M & Rajagopal, L 2016, 'Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate', Nature Medicine, vol. 22, no. 11, pp. 1256-1259. https://doi.org/10.1038/nm.4193

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abstract = "We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.",

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AU - Rajagopal, Lakshmi

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Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate

Abstract

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