Fe3O4 incorporated AOT-alginate nanoparticles for drug delivery

Chandran Sudakar, Ambesh Dixit, Rajesh Regmi, Ratna Naik, Gavin Lawes, Vaman M. Naik, Prem P. Vaishnava, Udaya Toti, Jayanth Panyam

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Composite nanoparticles of aerosol OT-alginate hydrogel loaded with Fe 3O4 and rhodamine 6G (R6G) in average diameter between 25 nm and 50 nm were synthesized by emulsification-cross-linking process and characterized by transmission electron microscopy (TEM) and SQUID magnetometery measurements. TEM measurements show that the Fe3O4 particles are uniformly distributed within AOT-alginate nanoparticles. The Ca2+ cross-linked AOT-alginate nanoparticles loaded with Fe 3O4 and rhodamine showed superparamagnetic behavior at room temperature with saturation magnetization of ∼50 emu/g of Fe 3O4. Similar behavior was exhibited by Fe2+ cross-linked AOT-alginate nanoparticles loaded with Fe3O4 and rhodamine except it showed twice the magnetization of Ca2+ crosslinked counterpart. A decrease in the amount of rhodamine loading for the composite nanoparticle systems as compared to the bare AOT-alginate nanoparticles was found.

Original languageEnglish (US)
Pages (from-to)2800-2803
Number of pages4
JournalIEEE Transactions on Magnetics
Volume44
Issue number11 PART 1
DOIs
StatePublished - Nov 2008

Keywords

  • Drug delivery
  • Magnetite
  • Polymer composite nanoparticles
  • Superparamagnetic properties

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