Fe3O4 incorporated AOT-alginate nanoparticles for drug delivery

Chandran Sudakar, Ambesh Dixit, Rajesh Regmi, Ratna Naik, Gavin Lawes, Vaman M. Naik, Prem P. Vaishnava, Udaya Toti, Jayanth Panyam

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Composite nanoparticles of aerosol OT-alginate hydrogel loaded with Fe 3 O4 and rhodamine 6G (R6G) in average diameter between 25 nm and 50 nm were synthesized by emulsification-cross-linking process and characterized by transmission electron microscopy (TEM) and SQUID magnetometery measurements. TEM measurements show that the Fe3 O4 particles are uniformly distributed within AOT-alginate nanoparticles. The Ca 2+ cross-linked AOT-alginate nanoparticles loaded with Fe 3O4 and rhodamine showed superparamagnetic behavior at room temperature with saturation magnetization of ∼50 emu/g of Fe 3O4. Similar behavior was exhibited by Fe 2+ crosslinked AOT-alginate nanoparticles loaded with Fe3O4 and rhodamine except it showed twice the magnetization of Ca 2+ crosslinked counterpart. A decrease in the amount of rhodamine loading for the composite nanoparticle systems as compared to the bare AOT-alginate nanoparticles was found.

Original languageEnglish (US)
Pages (from-to)2800-2803
Number of pages4
JournalIEEE Transactions on Magnetics
Volume44
Issue number11 PART 2
DOIs
StatePublished - Nov 2008

Bibliographical note

Funding Information:
ACKNOWLEDGMENT The authors would like to acknowledge the Richard Barber Funds for interdisciplinary Research, the Institute for Manufacturing Research at Wayne State University, and the donors of the American Chemical Society (PRF#46160-G10) for supporting the work.

Keywords

  • Drug delivery
  • Magnetite
  • Polymer composite nanoparticles
  • Superparamagnetic properties

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