Fertility treatment in the forty and older woman

Anthony Auyeung; Molly E. Klein; Valerie S. Ratts; Randall R. Odem; Daniel B. Williams

doi:10.1023/A:1013159116180

Fertility treatment in the forty and older woman

Anthony Auyeung, Molly E. Klein, Valerie S. Ratts, Randall R. Odem, Daniel B. Williams

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article

10 Scopus citations

Abstract

Purpose: To determine the outcomes and logical progression of fertility treatment in women forty years and older using their own oocytes. Methods: This was a retrospective study in which 401 completed treatment cycles in 152 women aged forty and older were reviewed. Results: Assisted reproductive technology (ART) cycles (n = 58) were reviewed, comprising both in vitro fertilization (IVF) and gamete intrafallopian transfer (GIFT). Intrauterine insemination (IUI) cycles (n = 343) were reviewed, consisting of 38 unstimulated natural cycle-IUI (NC-IUI), 194 clomiphene citrate-IUI (CC-IUI), and 111 injectable gonadotropins-IUI (INJ-IUI) cycles. The live birth rate of 15.5% for ART cycles was significantly higher than the live birth rate of 3.2 % seen for all IUI cycles (p = 0.0007). There were no differences among treatment groups in spontaneous abortion, preterm delivery, or ectopic pregnancy rates. Conclusions: For women ≥40 years of age who wish to use their own eggs, ART offers the best chances for conception and delivery.

Original language	English (US)
Article number	362188
Pages (from-to)	638-643
Number of pages	6
Journal	Journal of Assisted Reproduction and Genetics
Volume	18
Issue number	12
DOIs	https://doi.org/10.1023/A:1013159116180
State	Published - 2001

Keywords

Advanced reproductive age
Assisted reproductive technology
Intrauterine insemination
Ovulation induction

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Auyeung, A., Klein, M. E., Ratts, V. S., Odem, R. R., & Williams, D. B. (2001). Fertility treatment in the forty and older woman. Journal of Assisted Reproduction and Genetics, 18(12), 638-643. [362188]. https://doi.org/10.1023/A:1013159116180

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N2 - Purpose: To determine the outcomes and logical progression of fertility treatment in women forty years and older using their own oocytes. Methods: This was a retrospective study in which 401 completed treatment cycles in 152 women aged forty and older were reviewed. Results: Assisted reproductive technology (ART) cycles (n = 58) were reviewed, comprising both in vitro fertilization (IVF) and gamete intrafallopian transfer (GIFT). Intrauterine insemination (IUI) cycles (n = 343) were reviewed, consisting of 38 unstimulated natural cycle-IUI (NC-IUI), 194 clomiphene citrate-IUI (CC-IUI), and 111 injectable gonadotropins-IUI (INJ-IUI) cycles. The live birth rate of 15.5% for ART cycles was significantly higher than the live birth rate of 3.2 % seen for all IUI cycles (p = 0.0007). There were no differences among treatment groups in spontaneous abortion, preterm delivery, or ectopic pregnancy rates. Conclusions: For women ≥40 years of age who wish to use their own eggs, ART offers the best chances for conception and delivery.

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