Fertility drug use and the risk of ovarian tumors in infertile women: A case-control study

Albert Asante, Phoebe H Leonard, Amy L. Weaver, Ellen L. Goode, Jani R. Jensen, Elizabeth A. Stewart, Charles C. Coddington

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Objective: To assess the influence of infertility and fertility drugs on risk of ovarian tumors. Design: Case-control study (Mayo Clinic Ovarian Cancer Study). Setting: Ongoing academic study of ovarian cancer. Patient(s): A total of 1,900 women (1,028 with ovarian tumors and 872 controls, frequency matched on age and region of residence) who had provided complete information in a self-report questionnaire about history of infertility and fertility drug use. Intervention(s): None. Main Outcome Measure(s): Effect of infertility history, use of fertility drugs and oral contraception, and gravidity on the risk of ovarian tumor development, after controlling for potential confounders. Result(s): Among women who had a history of infertility, use of fertility drugs was reported by 44 (24%) of 182 controls and 38 (17%) of 226 cases. Infertile women who used fertility drugs were not at increased risk of developing ovarian tumors compared with infertile women who did not use fertility drugs; the adjusted odds ratio was 0.64 (95% CI, 0.37, 1.11). The findings were similar when stratified by gravidity and when analyzed separately for borderline versus invasive tumors. Conclusion(s): We found no statistically significant association between fertility drug use and risk of ovarian tumors. Further larger, prospective studies are needed to confirm this observation.

Original languageEnglish (US)
Pages (from-to)2031-2036
Number of pages6
JournalFertility and Sterility
Issue number7
StatePublished - Jun 2013

Bibliographical note

Funding Information:
Supported by National Institutes of Health grants R01 CA122443 , P50 CA136393 , and the Mayo Foundation .


  • Borderline tumors
  • case control
  • fertility drugs
  • ovarian tumors
  • primary infertility


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