Female pseudohermaphroditism due to congenital adrenal hyperplasia complicated by adenocarcinoma of the prostate and clear cell carcinoma of the endometrium

Jeffrey L. Winters, Phillip H. Chapman, Deborah E. Powell, Evelyn R. Banks, William R. Allen, David P. Wood

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The presence of prostatic glandular tissue in female pseudohermaphrodites has previously been documented. However, prostatic neoplasia in this clinical setting has not been reported. A karyotypic female with congenital adrenal hyperplasia due to 21-hydroxylase deficiency developed a prostatic adenocarcinoma associated with elevated serum prostatic specific antigen levels and osteoblastic skeletal metastases. This demonstrates that this tissue in pseudohermaphrodites can become malignant. In addition, the patient subsequently developed clear cell carcinoma of the endometrium, possibly related to radiation therapy for the prostatic adenocarcinoma. This demonstrates that female pseudohermaphrodites may be at risk not only for malignancies seen in genotypic females but also prostate cancer.

Original languageEnglish (US)
Pages (from-to)660-664
Number of pages5
JournalAmerican journal of clinical pathology
Volume106
Issue number5
DOIs
StatePublished - Nov 1996

Keywords

  • 21-hydroxylase deficiency
  • Clear cell carcinoma of the endometrium
  • Congenital adrenal hyperplasia
  • Prostatic adenocarcinoma
  • Pseudohermaphrodite

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