Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands

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It has been reported that intraventricular administration of the melanocortin 4 receptor (MC4-R) agonist MT II and antagonist SHU9119 alter food intake. We found that MT II and SHU9119 have extremely potent effects on feeding when injected in the paraventricular nucleus (PVN), a site where MC4- R gene expression is very high. Our finding provides direct evidence that MC4-R signaling is important is mediating food intake and that melanocortin neurons in the PVN exert a tonic inhibition of feeding behavior. Chronic disruption of this inhibitory signal is a possible explanation of the agouti- obesity syndrome.

Original languageEnglish (US)
Pages (from-to)302-306
Number of pages5
JournalBrain Research
Issue number2
StatePublished - Nov 2 1998


  • Food intake
  • MC4-receptor
  • MT II
  • Paraventricular nucleus
  • SHU9119

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