Feedback regulation of kinase signaling pathways by AREs and GREs

Irina Vlasova-St. Louis, Paul R. Bohjanen

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

In response to environmental signals, kinases phosphorylate numerous proteins, including RNA-binding proteins such as the AU-rich element (ARE) binding proteins, and the GU-rich element (GRE) binding proteins. Posttranslational modifications of these proteins lead to a significant changes in the abundance of target mRNAs, and affect gene expression during cellular activation, proliferation, and stress responses. In this review, we summarize the effect of phosphorylation on the function of ARE-binding proteins ZFP36 and ELAVL1 and the GRE-binding protein CELF1. The networks of target mRNAs that these proteins bind and regulate include transcripts encoding kinases and kinase signaling pathways (KSP) components. Thus, kinase signaling pathways are involved in feedback regulation, whereby kinases regulate RNA-binding proteins that subsequently regulate mRNA stability of ARE-or GRE-containing transcripts that encode components of KSP.

Original languageEnglish (US)
JournalCells
Volume5
Issue number1
DOIs
StatePublished - Jan 25 2016

Bibliographical note

Publisher Copyright:
© 2016 by the authors; licensee MDPI, Basel, Switzerland.

Keywords

  • ARE-GRE-mRNA stability
  • CELF1
  • ELAVL1
  • Kinase signaling
  • Posttranscriptional gene regulation
  • ZFP36

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