Feedback mechanisms regulate Ets variant 2 (Etv2) gene expression and hematoendothelial lineages

Naoko Koyano-Nakagawa; Xiaozhong Shi; Tara L. Rasmussen; Satyabrata Das; Camille A. Walter; Daniel J. Garry

doi:10.1074/jbc.M115.662197

Feedback mechanisms regulate Ets variant 2 (Etv2) gene expression and hematoendothelial lineages

Naoko Koyano-Nakagawa, Xiaozhong Shi, Tara L. Rasmussen, Satyabrata Das, Camille A. Walter, Daniel J. Garry

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Background: Although Etv2 is an essential transcriptional regulator during embryogenesis, the transcriptional regulation of Etv2 gene expression is not well understood. Results: Multiple signaling cascades were defined as regulators of Etv2 gene expression. Conclusion: These studies define upstream and downstream networks to regulate Etv2 gene expression. Significance: This is the first report to comprehensively characterize the transcriptional regulation of Etv2 gene expression.

Original language	English (US)
Pages (from-to)	28107-28119
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	290
Issue number	47
DOIs	https://doi.org/10.1074/jbc.M115.662197
State	Published - Nov 20 2015

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.

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abstract = "Background: Although Etv2 is an essential transcriptional regulator during embryogenesis, the transcriptional regulation of Etv2 gene expression is not well understood. Results: Multiple signaling cascades were defined as regulators of Etv2 gene expression. Conclusion: These studies define upstream and downstream networks to regulate Etv2 gene expression. Significance: This is the first report to comprehensively characterize the transcriptional regulation of Etv2 gene expression.",

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AU - Koyano-Nakagawa, Naoko

AU - Shi, Xiaozhong

AU - Rasmussen, Tara L.

AU - Das, Satyabrata

AU - Walter, Camille A.

AU - Garry, Daniel J.

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AB - Background: Although Etv2 is an essential transcriptional regulator during embryogenesis, the transcriptional regulation of Etv2 gene expression is not well understood. Results: Multiple signaling cascades were defined as regulators of Etv2 gene expression. Conclusion: These studies define upstream and downstream networks to regulate Etv2 gene expression. Significance: This is the first report to comprehensively characterize the transcriptional regulation of Etv2 gene expression.

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Feedback mechanisms regulate Ets variant 2 (Etv2) gene expression and hematoendothelial lineages

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