Feasibility of using £mri to study mothers responding to infant cries

Jeffrey P. Lorberbaum, John D. Newman, Judy R. Dubno, Amy R. Horwitz, Ziad Nahas, Charlotte C. Teneback, Courtnay W. Bloomer, Daryl E. Bohning, Diana Vincent, Michael R.johnson, Naresh Emmanuel, Olga Brawman-Mintzer, Sarah W. Book, Bruce Lydiard, James C. Ballenger, Mark S. George

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

While parenting is a universal human behavior, its neuroanatomic basis is currently unknown. Animal data suggest that the cingulate may play an important function in mammalian parenting behavior. For example, in rodents cingulate lesions impair maternal behavior. Here, in an attempt to understand the brain basis of human maternal behavior, we had mothers listen to recorded infant cries and white noise control sounds while they underwent functional MRI (fMRI) of the brain. We hypothesized that mothers would show significantly greater cingulate activity during the cries compared to the control sounds. Of 7 subjects scanned, 4 had fMRI data suitable for analysis. When fMRI data were averaged for these 4 subjects, the anterior cingulate and right medial prefrontal cortex were the only brain regions showing statistically increased activity with the cries compared to white noise control sounds (cluster analysis with one-tailed z-map threshold of P < 0.001 and spatial extent threshold of P < 0.05). These results demonstrate the feasibility of using fMRI to study brain activity in mothers listening to infant cries and that the anterior cingulate may be involved in mothers listening to crying babies. We are cun-ently replicating this study in a larger group of mothers. Future work in this area may help (1) unravel the functional neuroanatomy of the parentinfant bond and (2) examine whether markers of this bond, such as maternal brain response to infant ciying, can predict matenial style (i.e., child neglect), offspring temperament, or offspring depression or anxiety.

Original languageEnglish (US)
Pages (from-to)99-104
Number of pages6
JournalDepression and Anxiety
Volume10
Issue number3
DOIs
StatePublished - Jan 1 1999

Keywords

  • Anterior cingiilate
  • Attachment
  • Fmri
  • Imaging
  • Infant ciying
  • MRI
  • Maternal behavior
  • Social bonding

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    Lorberbaum, J. P., Newman, J. D., Dubno, J. R., Horwitz, A. R., Nahas, Z., Teneback, C. C., Bloomer, C. W., Bohning, D. E., Vincent, D., R.johnson, M., Emmanuel, N., Brawman-Mintzer, O., Book, S. W., Lydiard, B., Ballenger, J. C., & George, M. S. (1999). Feasibility of using £mri to study mothers responding to infant cries. Depression and Anxiety, 10(3), 99-104. https://doi.org/10.1002/(SICI)1520-6394(1999)10:3<99::AID-DA2>3.0.CO;2-#