Feasibility of single-voxel MRS measurement of apparent diffusion coefficient of water in breast tumors

Curtis A. Corum, A. D. McIntosh, P. J. Bolan, M. Nelson, A. L. Snyder, N. J. Powell, J. Boyum, T. H. Emory, D. Yee, T. M. Tuttle, L. I. Everson, M. Garwood

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4 Scopus citations


We report initial results with single voxel spectroscopy (SVS) using diffusion weighting and localization by adiabatic selective refocusing (LASER) in breast tumors to measure the apparent diffusion coefficient of water (ADCw). This is a quick (30 s) and relatively easy method to implement compared with image-based diffusion measurements, and is insensitive to lipid signal contamination. The ADCw and concentration of total choline containing compounds [tCho] were evaluated for associations with each other and final pathologic diagnosis in 25 subjects. The average (± SD) ADCw in benign and malignant lesions was 1.96 ± 0.47 mm2/s and 1.26 ± 0.29 × 10-3 mm2/s, respectively, P< 0.001. Receiver operating characteristic curve analysis showed an area under the curve of 0.92. Analysis of the single voxel (SV) ADCw and [tCho] showed significant correlation with a R2 of 0.56, P< 0.001. Compared with more commonly used image-based methods of measuring water ADC, SV-ADCw is faster, more robust, insensitive to fat, and potentially easier to implement on standard clinical systems.

Original languageEnglish (US)
Pages (from-to)1232-1237
Number of pages6
JournalMagnetic resonance in medicine
Issue number5
StatePublished - May 2009


  • ADC
  • ADCw
  • Breast cancer
  • Choline
  • Diffusion
  • tCho


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