Feasibility of prolonged continuous glucose monitoring in toddlers with type 1 diabetes

Eva Tsalikian, Larry Fox, Stuart Weinzimer, Bruce Buckingham, Neil H. White, Roy Beck, Craig Kollman, Dongyuan Xing, Katrina Ruedy, Nelly Mauras, Larry A. Fox, Kim Englert, Joe Permuy, Bruce A. Buckingham, Darrell M. Wilson, Paula Clinton, Kimberly Caswell, Stuart A. Weinzimer, William V. Tamborlane, Jennifer SherrAmy Steffen, Kate Weyman, Neil H. White, Ana Maria Arbelaez, Lucy Levandoski, Angie Starnes, Roy W. Beck, Katrina J. Ruedy, Craig Kollman, Dongyuan Xing, Gilman D. Grave, Karen K. Winer, Ellen Leschek, Mark Sperling, Dorothy M. Becker, Patricia Cleary, Carla Greenbaum, Antoinette Moran

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Objective: To examine the feasibility of continuous glucose monitoring (CGM) use in very young children with type 1 diabetes (T1D). Research design and methods: Twenty-three children less than 4 yr of age with T1D were provided with a FreeStyle Navigator® (n = 21) or a Paradigm® (n = 2) CGM device. At baseline, mean age was 3.0 ± 0.8 yr, mean hemoglobin A1c (HbA1c) was 8.0 ± 0.8%, 10 were using an insulin pump and 13 were on multiple daily injections. CGM use was evaluated over a 6-month period. Results: Three children dropped out of the study before the end of 6 months. Among the 20 children who completed 6 months of follow-up, CGM use in month 6 was ≥6 d/wk in 9 (45%), 4 ≤ 6 d/wk in 2 (10%), and <4 d/wk in 9 (45%). Skin reactions were minimal. Although there was no detectable change in mean HbA1c between baseline and 6 months (7.9 and 8.0%, respectively), there was a high degree of parental satisfaction with CGM as measured on the CGM satisfaction scale questionnaire. A high percentage of glucose values were in the hyperglycemic range, and biochemical hypoglycemia was infrequent. Conclusion: More than 40% of very young children were able to safely use CGM on a near-daily basis after 6 months. CGM demonstrated frequent hyperglycemic excursions, with a large variability in glucose readings. Although improvement in glycemic control was not detected in the group as a whole, parental satisfaction with CGM was high.

Original languageEnglish (US)
Pages (from-to)301-307
Number of pages7
JournalPediatric Diabetes
Volume13
Issue number4
DOIs
StatePublished - Jun 1 2012

Keywords

  • CGM
  • T1D
  • Young children

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