Feasibility of intrafraction whole-body motion tracking for total marrow irradiation

Manju Sharma, Troy Dos Santos, Nikolaos P Papanikolopoulos, Susanta Kumar Huia

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


With image-guided tomotherapy, highly targeted total marrow irradiation (TMI) has become a feasible alternative to conventional total body irradiation. The uncertainties in patient localization and intrafraction motion of the whole body during hour-long TMI treatment may pose a risk to the safety and accuracy of targeted radiation treatment. The feasibility of near-infrared markers and optical tracking system (OTS) is accessed along with a megavoltage scanning system of tomotherapy. Three near-infrared markers placed on the face of a rando phantom are used to evaluate the capability of OTS in measuring changes in the markers' positions as the rando is moved in the translational direction. The OTS is also employed to determine breathing motion related changes in the position of 16 markers placed on the chest surface of human volunteers. The maximum uncertainty in locating marker position with the OTS is 1.5 mm. In the case of normal and deep breathing motion, the maximum marker position change is observed in anterior-posterior direction with the respective values of 4 and 12 mm. The OTS is able to measure surface changes due to breathing motion. The OTS may be optimized to monitor whole body motion during TMI to increase the accuracy of treatment delivery and reduce the radiation dose to the lungs.

Original languageEnglish (US)
Article number058002
JournalJournal of biomedical optics
Issue number5
StatePublished - May 2011

Bibliographical note

Funding Information:
This research was supported by the National Science Foundation (NSF No. CNS-0821474), the Digital Technology Center, and the Medical device grant at the University of Minnesota. This work was also supported by PHS Cancer Center Support Grant No. P30 CA77398. The authors thank Motion Analysis Corporation for providing the motion tracking cameras.


  • Megavoltage scanning system
  • Motion tracking
  • Near-infrared maker
  • Total marrow irradiation


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