Feasibility of BU, CY and etoposide (BUCYE), and auto-SCT in patients with newly diagnosed primary CNS lymphoma: A single-center experience

D. H. Yoon, D. H. Lee, D. R. Choi, B. S. Sohn, S. Kim, S. W. Kim, J. S. Lee, S. W. Lee, J. Huh, C. Suh

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

We investigated the feasibility of i.v. BU, CY and etoposide (BUCYE), followed by auto-SCT (ASCT) in patients with newly diagnosed primary central nervous system lymphoma (PCNSL). The planned treatment consisted of induction chemotherapy with five cycles of high-dose MTX and two cycles of high-dose cytarabine followed by conditioning with BUCYE (BU 3.2 mg/m2, day 7 to day 5; CY 50 mg/kg, day 3 to day 2 and etoposide 200 mg/m2, twice a day, days 5 and 4) and then ASCT. Between May 2005 and November 2008, 11 consecutive PCNSL patients were treated. All patients completed the treatment as planned, with no cases of treatment-related death or veno-occlusive disease. After BUCYE and ASCT, 10 patients achieved complete response (CR) or unconfirmed CR (CRu). Two patients, one partial response and one CRu, received further whole-brain radiotherapy, with all achieving CR. At a median follow-up of 25.0 months (8.8-50.7 months), six patients had relapsed, with a median event-free interval of 15.0 months (95% confidence interval, 4.5-25.6 months). Median survival time was not reached yet with a 2-year survival rate of 88.9%. The current treatment was feasible with a favorable tolerance profile. However, further regimen optimization is necessary because of high relapse rate.

Original languageEnglish (US)
Pages (from-to)105-109
Number of pages5
JournalBone marrow transplantation
Volume46
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • BU
  • CY
  • auto-SCT
  • etoposide
  • primary CNS lymphoma

Fingerprint Dive into the research topics of 'Feasibility of BU, CY and etoposide (BUCYE), and auto-SCT in patients with newly diagnosed primary CNS lymphoma: A single-center experience'. Together they form a unique fingerprint.

Cite this