Feasibility experiments for the development of a midbrain auditory prosthesis

Hubert H. Lim, David J. Anderson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Scopus citations

Abstract

This paper presents a new approach for hearing restoration in patients suffering from sensorineural hearing loss. We focus on the development of a midbrain auditory prosthesis, implanted into the central nucleus of the inferior colliculus (ICC). We performed experiments in a guinea pig model to initially explore the tonotopic map that exists between ICC and the primary auditory cortex (A1), the initial center for auditory perception. Using multichannel electrodes, we were able to stimulate along 16 different ICC sites and simultaneously record from 16 different Al sites. Both electrodes were placed along similar tonotopic gradients. ICC stimulation in low frequency regions induced activity in low frequency regions of A1, and similar trends were seen for higher frequencies. ICC stimulation appears to be very specific, causing minimal spreading of activity across A1 sites, and stimulation threshold levels were significantly lower than that currently obtained using cochlear prostheses. These results indicate that an ICC-based auditory implant may provide a more focused means of stimulation at lower threshold levels for hearing restoration compared to current cochlear prostheses. The tonotopic map between ICC and A1 suggests that a frequency place code may be utilized in a midbrain auditory prosthesis.

Original languageEnglish (US)
Title of host publicationConference Proceedings - 1st International IEEE EMBS Conference on Neural Engineering
EditorsLaura J. Wolf, Jodi L. Strock
PublisherIEEE Computer Society
Pages193-196
Number of pages4
ISBN (Electronic)0780375793
DOIs
StatePublished - Jan 1 2003
Event1st International IEEE EMBS Conference on Neural Engineering - Capri Island, Italy
Duration: Mar 20 2003Mar 22 2003

Publication series

NameInternational IEEE/EMBS Conference on Neural Engineering, NER
Volume2003-January
ISSN (Print)1948-3546
ISSN (Electronic)1948-3554

Other

Other1st International IEEE EMBS Conference on Neural Engineering
CountryItaly
CityCapri Island
Period3/20/033/22/03

Keywords

  • Auditory implants
  • Auditory system
  • Brain modeling
  • Deafness
  • Electrodes
  • Frequency
  • Microphone arrays
  • Probes
  • Prosthetics
  • Silicon

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  • Cite this

    Lim, H. H., & Anderson, D. J. (2003). Feasibility experiments for the development of a midbrain auditory prosthesis. In L. J. Wolf, & J. L. Strock (Eds.), Conference Proceedings - 1st International IEEE EMBS Conference on Neural Engineering (pp. 193-196). [1196790] (International IEEE/EMBS Conference on Neural Engineering, NER; Vol. 2003-January). IEEE Computer Society. https://doi.org/10.1109/CNE.2003.1196790