Feasibility, acceptability and preliminary efficacy of an online peer-to-peer social support ART adherence intervention

Keith J. Horvath, J. Michael Oakes, B. R. Simon Rosser, Gene Danilenko, Heather Vezina, K. Rivet Amico, Mark L. Williams, Jane Simoni

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


This study describes the results of an online social support intervention, called "Thrive with Me" (TWM), to improve antiretroviral therapy (ART) adherence. HIV-positive gay or bisexually-identified men self-reporting imperfect ART adherence in the past month were randomized to receive usual care (n = 57) or the eight-week TWM intervention (n = 67). Self-reported ART outcome measures (0-100 % in the past month) were collected at baseline, post-intervention, and 1-month follow-up. Follow-up assessment completion rate was 90 %. Participants rated (1-7 scale) the intervention high in information and system quality and overall satisfaction (Means ≥ 5.0). The intervention showed modest effects for the overall sample. However, among current drug-using participants, the TWM (vs. Control) group reported significantly higher overall ART adherence (90.1 vs. 57.5 % at follow-up; difference = 31.1, p = 0.02) and ART taken correctly with food (81.6 vs. 55.7 % at follow-up; difference = 47.9, p = 0.01). The TWM intervention appeared feasible to implement, acceptable to users, and demonstrated greatest benefits for current drug users.

Original languageEnglish (US)
Pages (from-to)2031-2044
Number of pages14
JournalAIDS and Behavior
Issue number6
StatePublished - Jul 2013

Bibliographical note

Funding Information:
Acknowledgments We wish to thank the participants of this study for their time and effort. We also thank Tony Miles at the Positive Project for allowing us to use segments from their video archive for the purpose of this study. This study was funded by the National Institute of Mental Health (5R34MH083549).


  • Antiretroviral adherence
  • Internet-based intervention
  • Men who have sex with men
  • Social support


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