Abstract
The nucleophilic ferrate salt Bu4N[Fe(CO)3(NO)] (TBA[Fe]) is able to catalyze the direct trifluoromethylation of aldehydes and ketones using Me3SiCF3 as a trifluoromethylating agent. Interception of the C-Si I-bond activation using allylic acetates allows for a tandem trifluoromethylation-allylation of electron-deficient olefins. The higher activity of acetate in the C-Si bond activation and the selective Fe-catalyzed activation of the allylic acetate are prerequisites for this unprecedented three-component coupling reaction.
Original language | English (US) |
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Pages (from-to) | 5802-5810 |
Number of pages | 9 |
Journal | Organometallics |
Volume | 33 |
Issue number | 20 |
DOIs | |
State | Published - Oct 27 2014 |
Bibliographical note
Publisher Copyright:© 2014 American Chemical Society.