FBNTI, a DOR-Selective Antagonist That Allosterically Activates MOR within a MOR-DOR Heteromer

Keyphrases

• Heteromer 100%
• Selective Antagonist 100%
• Agonism 66%
• Protomers 66%
• Intrathecal 33%
• Antagonism 33%
• Opioid Receptors 33%
• Knock-in Mouse Model 33%
• Intrathecal Administration 33%
• Topical Administration 33%
• Allosteric Activation 33%
• Systemic Exposure 33%
• Highly Effective 33%
• Hargreaves 33%
• EC50 33%
• Antinociception 33%
• ED50 33%
• Hind Paw 33%
• HEK293 Cells 33%
• MOR Agonists 33%
• Pharmacological Profile 33%
• Contralateral Activity 33%
• Allosteric Mechanism 33%
• Calcium Mobilization Assay 33%
• MOR Antagonist 33%

Medicine and Dentistry

• Heteromer 100%
• Contralateral 33%
• Antinociception 33%
• Intrathecal Drug Administration 33%
• Hind Paw 33%
• HEK 293 Cells 33%
• Topical Drug Administration 33%
• Dextro Phenylalanylcysteinyltyrosyl Dextro Tryptophylornithylthreonylpenicillaminylthreoninamide 2,7 Disulfide 33%
• Calcium Mobilization Assay 33%
• Opioid Receptor 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Heteromer 100%
• Intrathecal 66%
• Knockout Mouse 33%
• Opiate Receptor 33%
• Antinociception 33%
• Dextro Phenylalanylcysteinyltyrosyl Dextro Tryptophylornithylthreonylpenicillaminylthreoninamide 2,7 Disulfide 33%
• EC50 33%