Favorable outcome of allogeneic hematopoietic cell transplantation for 8p11 myeloproliferative syndrome associated with BCR-FGFR1 gene fusion

Michelle Dolan, Adina Cioc, Nicholas C P Cross, Joseph P. Neglia, Jakub Tolar

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

We report the case of a child who presented with nonspecific symptoms suggestive of a rheumatologic disorder, whose bone marrow had a complex translocation involving the FGFR1 locus. Hematopathologic findings were subtle and did not definitively indicate malignancy. Because he responded poorly to initial treatment with hydroxyurea, and in light of the progressive clinical course associated with the 8p11 myeloproliferative syndrome, he underwent an unrelated-donor hematopoietic stem cell transplant. This patient's atypical presentation highlights the importance of obtaining cytogenetic analysis at the time of bone marrow sampling and considering this uncommon entity in the differential diagnosis of hematologic disorders.

Original languageEnglish (US)
Pages (from-to)194-196
Number of pages3
JournalPediatric Blood and Cancer
Volume59
Issue number1
DOIs
StatePublished - Jul 15 2012

Keywords

  • 8p11 myeloproliferative syndrome
  • BCR
  • BCR-FGFR1 gene fusion
  • FGFR1
  • Hematopoietic cell transplantation

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