Fatty acid trafficking in the adipocyte

David A. Bernlohr, Natalie Ribarik Coe, Vince J. LiCata

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The insolubility of fatty acids in cellular environments requires that specific trafficking mechanisms be developed to vectorally orient and deliver lipids for cellular needs. The roles of putative membrane bound fatty acid transporters and soluble carrier proteins are discussed in terms of mechanisms of fatty acid trafficking. The numerous roles for fatty acids as an energy source, as structural elements for membrane synthesis, as bioregulators and as prohormones with the potential to regulate gene expression, are discussed in terms of the necessity to regulate their intracellular location and concentration.

Original languageEnglish (US)
Pages (from-to)43-49
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume10
Issue number1
DOIs
StatePublished - Feb 1999

Bibliographical note

Funding Information:
This work supported by grants from the National Institutes of Health and the National Science Foundation.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

  • Fatty acid
  • Lipid-binding proteins
  • Metabolic control
  • Trafficking
  • Transporters

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