Fatty acid flux in adipocytes: The in's and out's of fat cell lipid trafficking

Brian R. Thompson, Sandra Lobo, David A. Bernlohr

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations

Abstract

The trafficking of fatty acids into and out of adipocytes is regulated by a complex series of proteins and enzymes and is under control by a variety of hormonal and metabolic factors. The biochemical basis of fatty acid influx, despite its widespread appreciation, remains enigmatic with regard to the biophysical and biochemical properties that facilitate long-chain fatty acid uptake. Fatty acid efflux is initiated by hormonally controlled lipolysis of the droplet stores and produces fatty acids that must transit from their site of production to the plasma membrane and subsequently out of the cells. This review will focus on the "in's and out's" of fatty acid trafficking and summarize the current concepts in the field.

Original languageEnglish (US)
Pages (from-to)24-33
Number of pages10
JournalMolecular and Cellular Endocrinology
Volume318
Issue number1-2
DOIs
StatePublished - Apr 29 2010

Keywords

  • Adipocytes
  • Efflux
  • Fatty acid
  • Influx
  • Trafficking

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