Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers. FAAH hydrolyzes a range of fatty acid amides, and the present study examines the relative rates of hydrolysis of a variety of natural and unnatural fatty acid primary amide substrates using pure recombinant rat FAAH. (C) 2000 Elsevier Science Ltd.
|Original language||English (US)|
|Number of pages||4|
|Journal||Bioorganic and Medicinal Chemistry Letters|
|State||Published - Dec 4 2000|
Bibliographical noteFunding Information:
We gratefully acknowledge the financial support of the Skaggs Institute for Chemical Biology, National Institutes of Health (CA42056, D.L.B.; MH58542, B.F.C.), fellowships for R.A.F. (American Cancer Society 576211) and M.P.P. (National Science Foundation), and the postdoctoral sabbatical leave of H.M. sponsored by Sumitomo Pharmaceuticals.