Fatal myocarditis associated with HHV-6 following immunosuppression in two children

Heather E. Stefanski, Kathryn A. Thibert, Joshua Pritchett, Bhupesh K. Prusty, John E. Wagner, Troy C. Lund

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9 Scopus citations


Fatal myocarditis is a rare complication in immunosuppressed children. Recent reports have linked human herpesvirus 6 (HHV-6) infection, typically a benign infection in childhood, with myocarditis. HHV-6 can reactivate during periods of immunosuppression. Here, we report 2 cases in which children were immunosuppressed, one for treatment of Evans syndrome and the other post hematopoietic stem cell transplantation, who developed rapid and fatal HHV-6-associated myocarditis. These cases suggest that HHV-6 infection should be considered as an etiology of myocarditis in immunosuppressed patients regardless of correlating blood levels. Early treatment of HHV-6 in patients with myocarditis could improve morbidity and mortality.

Original languageEnglish (US)
Article numbere20151352
Issue number1
StatePublished - Jan 2016

Bibliographical note

Publisher Copyright:
© 2016 by the American Academy of Pediatrics.


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