Fatal hyperammonemia after repeat renal transplantation

Roy K. Kiberenge; Humphrey Lam

doi:10.1016/j.jclinane.2014.09.008

Fatal hyperammonemia after repeat renal transplantation

Roy K. Kiberenge, Humphrey Lam

Anesthesiology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A 35-year-old man had symptomatic hyperammonemia and normal liver function after repeat kidney transplantation. He presented with gastrointestinal symptoms, which quickly progressed to altered mental status. Therapy was instituted to clear the ammonia, but the ammonia level continued to rise. Eventually, the patient became unresponsive, and an emergent computed tomographic scan showed cerebral herniation. Urine acids and serum organic acids were not diagnostic of any urea cycle disorder. Histology did not reveal a clear etiology for the hyperammonemia.

Original language	English (US)
Pages (from-to)	164-167
Number of pages	4
Journal	Journal of Clinical Anesthesia
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.jclinane.2014.09.008
State	Published - Mar 1 2015

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Inc. All rights reserved.

Keywords

Acid-base balance
Critical care issues
Drugs used in anesthesia and critical care medicine
Fluid management/replacement therapy
Kidney
Transplantation

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10.1016/j.jclinane.2014.09.008

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abstract = "A 35-year-old man had symptomatic hyperammonemia and normal liver function after repeat kidney transplantation. He presented with gastrointestinal symptoms, which quickly progressed to altered mental status. Therapy was instituted to clear the ammonia, but the ammonia level continued to rise. Eventually, the patient became unresponsive, and an emergent computed tomographic scan showed cerebral herniation. Urine acids and serum organic acids were not diagnostic of any urea cycle disorder. Histology did not reveal a clear etiology for the hyperammonemia.",

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AB - A 35-year-old man had symptomatic hyperammonemia and normal liver function after repeat kidney transplantation. He presented with gastrointestinal symptoms, which quickly progressed to altered mental status. Therapy was instituted to clear the ammonia, but the ammonia level continued to rise. Eventually, the patient became unresponsive, and an emergent computed tomographic scan showed cerebral herniation. Urine acids and serum organic acids were not diagnostic of any urea cycle disorder. Histology did not reveal a clear etiology for the hyperammonemia.

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KW - Critical care issues

KW - Drugs used in anesthesia and critical care medicine

KW - Fluid management/replacement therapy

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KW - Transplantation

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Fatal hyperammonemia after repeat renal transplantation

Abstract

Bibliographical note

Keywords

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