Fat-soluble vitamin deficiency is common in children with chronic pancreatitis undergoing total pancreatectomy with islet autotransplantation

Kendall R. McEachron; Elissa M. Downs; Sarah J. Schwarzenberg; Srinath Chinnakotla; Melena D. Bellin

doi:10.1097/mpg.0000000000002950

Fat-soluble vitamin deficiency is common in children with chronic pancreatitis undergoing total pancreatectomy with islet autotransplantation

Kendall R. McEachron, Elissa M. Downs, Sarah J. Schwarzenberg, Srinath Chinnakotla, Melena D. Bellin

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Abstract

ABSTRACT: The prevalence of fat-soluble vitamin (FSV) deficiency in children undergoing total pancreatectomy with islet autotransplantation (TPIAT) for chronic pancreatitis (CP) is unknown. We quantified FSV deficiency in 100 children (age ≤18) undergoing TPIAT. FSV levels (vitamins A, E, D) and clinical history were abstracted from medical records. Vitamin A was low in 4% before and 7% at 1 year after TPIAT, vitamin E in 17% and 18%, and vitamin D in 22% and 24%, respectively, regardless of pancreatic enzyme or vitamin supplement dosing. Longer duration of CP was associated with pre-TPIAT vitamin D insufficiency (P = 0.0002). This remained significant in a multivariate regression model (adjusted P = 0.01). On multivariate analysis, there were no significant predictors of low FSV levels post-TPIAT. FSV deficiencies are common among children undergoing TPIAT and patients who have had longer disease duration may be at increased risk. All children should be monitored for FSV deficiency after TPIAT.

Original language	English (US)
Pages (from-to)	123-126
Number of pages	4
Journal	Journal of pediatric gastroenterology and nutrition
Volume	72
Issue number	1
DOIs	https://doi.org/10.1097/mpg.0000000000002950
State	Published - Jan 2021

Bibliographical note

Funding Information:
University of Minnesota Medical School, Minneapolis, MN. Address correspondence and reprint requests to Kendall R. McEachron, MD, Department of Surgery, University of Minnesota Medical School, 420 Delaware Street SE,| Minneapolis, MN 55455 (e-mail: [email protected]). K.R.M. is supported by T32DK108733. M.D.B. is supported by R01DK109124. The authors report no conflicts of interest. Copyright © 2020 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition DOI: 10.1097/MPG.0000000000002950

Publisher Copyright:
Copyright # 2020.

Keywords

Exocrine pancreatic insufficiency
Fat-soluble vitamins
Pancreatectomy
Total pancreatectomy with islet autotransplantation
Avitaminosis
Pancreatectomy/adverse effects
Humans
Islets of Langerhans Transplantation
Transplantation, Autologous
Pancreatitis, Chronic/surgery
Child
Vitamins

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural

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10.1097/mpg.0000000000002950

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Fat-soluble vitamin deficiency is common in children with chronic pancreatitis undergoing total pancreatectomy with islet autotransplantation. / McEachron, Kendall R.; Downs, Elissa M.; Schwarzenberg, Sarah J. et al.
In: Journal of pediatric gastroenterology and nutrition, Vol. 72, No. 1, 01.2021, p. 123-126.

Research output: Contribution to journal › Article › peer-review

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title = "Fat-soluble vitamin deficiency is common in children with chronic pancreatitis undergoing total pancreatectomy with islet autotransplantation",

abstract = "ABSTRACT: The prevalence of fat-soluble vitamin (FSV) deficiency in children undergoing total pancreatectomy with islet autotransplantation (TPIAT) for chronic pancreatitis (CP) is unknown. We quantified FSV deficiency in 100 children (age ≤18) undergoing TPIAT. FSV levels (vitamins A, E, D) and clinical history were abstracted from medical records. Vitamin A was low in 4% before and 7% at 1 year after TPIAT, vitamin E in 17% and 18%, and vitamin D in 22% and 24%, respectively, regardless of pancreatic enzyme or vitamin supplement dosing. Longer duration of CP was associated with pre-TPIAT vitamin D insufficiency (P = 0.0002). This remained significant in a multivariate regression model (adjusted P = 0.01). On multivariate analysis, there were no significant predictors of low FSV levels post-TPIAT. FSV deficiencies are common among children undergoing TPIAT and patients who have had longer disease duration may be at increased risk. All children should be monitored for FSV deficiency after TPIAT.",

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AU - Schwarzenberg, Sarah J.

AU - Chinnakotla, Srinath

AU - Bellin, Melena D.

N1 - Funding Information: University of Minnesota Medical School, Minneapolis, MN. Address correspondence and reprint requests to Kendall R. McEachron, MD, Department of Surgery, University of Minnesota Medical School, 420 Delaware Street SE,| Minneapolis, MN 55455 (e-mail: [email protected]). K.R.M. is supported by T32DK108733. M.D.B. is supported by R01DK109124. The authors report no conflicts of interest. Copyright © 2020 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition DOI: 10.1097/MPG.0000000000002950 Publisher Copyright: Copyright # 2020.

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N2 - ABSTRACT: The prevalence of fat-soluble vitamin (FSV) deficiency in children undergoing total pancreatectomy with islet autotransplantation (TPIAT) for chronic pancreatitis (CP) is unknown. We quantified FSV deficiency in 100 children (age ≤18) undergoing TPIAT. FSV levels (vitamins A, E, D) and clinical history were abstracted from medical records. Vitamin A was low in 4% before and 7% at 1 year after TPIAT, vitamin E in 17% and 18%, and vitamin D in 22% and 24%, respectively, regardless of pancreatic enzyme or vitamin supplement dosing. Longer duration of CP was associated with pre-TPIAT vitamin D insufficiency (P = 0.0002). This remained significant in a multivariate regression model (adjusted P = 0.01). On multivariate analysis, there were no significant predictors of low FSV levels post-TPIAT. FSV deficiencies are common among children undergoing TPIAT and patients who have had longer disease duration may be at increased risk. All children should be monitored for FSV deficiency after TPIAT.

AB - ABSTRACT: The prevalence of fat-soluble vitamin (FSV) deficiency in children undergoing total pancreatectomy with islet autotransplantation (TPIAT) for chronic pancreatitis (CP) is unknown. We quantified FSV deficiency in 100 children (age ≤18) undergoing TPIAT. FSV levels (vitamins A, E, D) and clinical history were abstracted from medical records. Vitamin A was low in 4% before and 7% at 1 year after TPIAT, vitamin E in 17% and 18%, and vitamin D in 22% and 24%, respectively, regardless of pancreatic enzyme or vitamin supplement dosing. Longer duration of CP was associated with pre-TPIAT vitamin D insufficiency (P = 0.0002). This remained significant in a multivariate regression model (adjusted P = 0.01). On multivariate analysis, there were no significant predictors of low FSV levels post-TPIAT. FSV deficiencies are common among children undergoing TPIAT and patients who have had longer disease duration may be at increased risk. All children should be monitored for FSV deficiency after TPIAT.

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KW - Islets of Langerhans Transplantation

KW - Transplantation, Autologous

KW - Pancreatitis, Chronic/surgery

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KW - Vitamins

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ER -

Fat-soluble vitamin deficiency is common in children with chronic pancreatitis undergoing total pancreatectomy with islet autotransplantation

Abstract

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Keywords

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