Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding

Bryan A. Krantz; Leland Mayne; Jon Rumbley; S. Walter Englander; Tobin R. Sosnick

doi:10.1016/S0022-2836(02)01029-X

Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding

Bryan A. Krantz, Leland Mayne, Jon Rumbley, S. Walter Englander, Tobin R. Sosnick

Pharmacy Practice and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

151 Scopus citations

Abstract

Do stable intermediates form very early in the protein folding process? New results and a quantity of literature that bear on this issue are examined here. Results available provide little support for early intermediate accumulation before an initial search-dependent nucleation barrier.

Original language	English (US)
Pages (from-to)	359-371
Number of pages	13
Journal	Journal of Molecular Biology
Volume	324
Issue number	2
DOIs	https://doi.org/10.1016/S0022-2836(02)01029-X
State	Published - 2002

Bibliographical note

Funding Information:
We thank Y. Bai, D. Baker, R. L. Baldwin, W. Eaton, N. R. Kallenbach, I. Morishima, T. Pan, S. Radford, H. Roder, D. Rousseau, and members of our groups for numerous helpful discussions. This work was supported by grants from the NIH, the Mathers Foundation, and the Packard Foundation Interdisciplinary Science Program.

Keywords

Barriers in protein folding
Burst phase
Initial barrier hypothesis
Intermediates in protein folding
Protein folding

Publisher link

10.1016/S0022-2836(02)01029-X

Find It

Find It at U of M Libraries

Cite this

@article{3c4a9b68e21c43d49878e21b1c141670,

title = "Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding",

abstract = "Do stable intermediates form very early in the protein folding process? New results and a quantity of literature that bear on this issue are examined here. Results available provide little support for early intermediate accumulation before an initial search-dependent nucleation barrier.",

keywords = "Barriers in protein folding, Burst phase, Initial barrier hypothesis, Intermediates in protein folding, Protein folding",

author = "Krantz, {Bryan A.} and Leland Mayne and Jon Rumbley and Englander, {S. Walter} and Sosnick, {Tobin R.}",

note = "Funding Information: We thank Y. Bai, D. Baker, R. L. Baldwin, W. Eaton, N. R. Kallenbach, I. Morishima, T. Pan, S. Radford, H. Roder, D. Rousseau, and members of our groups for numerous helpful discussions. This work was supported by grants from the NIH, the Mathers Foundation, and the Packard Foundation Interdisciplinary Science Program.",

year = "2002",

doi = "10.1016/S0022-2836(02)01029-X",

language = "English (US)",

volume = "324",

pages = "359--371",

journal = "Journal of Molecular Biology",

issn = "0022-2836",

publisher = "Academic Press",

number = "2",

}

TY - JOUR

T1 - Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding

AU - Krantz, Bryan A.

AU - Mayne, Leland

AU - Rumbley, Jon

AU - Englander, S. Walter

AU - Sosnick, Tobin R.

N1 - Funding Information: We thank Y. Bai, D. Baker, R. L. Baldwin, W. Eaton, N. R. Kallenbach, I. Morishima, T. Pan, S. Radford, H. Roder, D. Rousseau, and members of our groups for numerous helpful discussions. This work was supported by grants from the NIH, the Mathers Foundation, and the Packard Foundation Interdisciplinary Science Program.

PY - 2002

Y1 - 2002

N2 - Do stable intermediates form very early in the protein folding process? New results and a quantity of literature that bear on this issue are examined here. Results available provide little support for early intermediate accumulation before an initial search-dependent nucleation barrier.

AB - Do stable intermediates form very early in the protein folding process? New results and a quantity of literature that bear on this issue are examined here. Results available provide little support for early intermediate accumulation before an initial search-dependent nucleation barrier.

KW - Barriers in protein folding

KW - Burst phase

KW - Initial barrier hypothesis

KW - Intermediates in protein folding

KW - Protein folding

UR - http://www.scopus.com/inward/record.url?scp=0036440985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036440985&partnerID=8YFLogxK

U2 - 10.1016/S0022-2836(02)01029-X

DO - 10.1016/S0022-2836(02)01029-X

M3 - Article

C2 - 12441113

AN - SCOPUS:0036440985

SN - 0022-2836

VL - 324

SP - 359

EP - 371

JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

IS - 2

ER -

Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding

Abstract

Bibliographical note

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this