Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding

Bryan A. Krantz, Leland Mayne, Jon Rumbley, S. Walter Englander, Tobin R. Sosnick

Research output: Contribution to journalArticlepeer-review

144 Scopus citations

Abstract

Do stable intermediates form very early in the protein folding process? New results and a quantity of literature that bear on this issue are examined here. Results available provide little support for early intermediate accumulation before an initial search-dependent nucleation barrier.

Original languageEnglish (US)
Pages (from-to)359-371
Number of pages13
JournalJournal of Molecular Biology
Volume324
Issue number2
DOIs
StatePublished - Jan 1 2002

Keywords

  • Barriers in protein folding
  • Burst phase
  • Initial barrier hypothesis
  • Intermediates in protein folding
  • Protein folding

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