Fast and accurate quantification using genetic algorithm optimized 1H-13C refocused constant-time INEPT

V. S. Manu; Anil Kumar

doi:10.1016/j.jmr.2013.06.013

Fast and accurate quantification using genetic algorithm optimized ¹H-¹³C refocused constant-time INEPT

V. S. Manu
, Anil Kumar

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Using Genetic Algorithm, a global optimization method inspired by nature's evolutionary process, we have improved the quantitative refocused constant-time INEPT experiment (Q-INEPT-CT) of Mäkelä et al. (JMR 204 (2010) 124-130) with various optimization constraints. The improved 'average polarization transfer' and 'min-max difference' of new delay sets effectively reduces the experimental time by a factor of two (compared with Q-INEPT-CT, Mäkelä et al.) without compromising on accuracy. We also discuss a quantitative spectral editing technique based on average polarization transfer.

Original language	English (US)
Pages (from-to)	106-111
Number of pages	6
Journal	Journal of Magnetic Resonance
Volume	234
DOIs	https://doi.org/10.1016/j.jmr.2013.06.013
State	Published - 2013
Externally published	Yes

Bibliographical note

Funding Information:
We thank NMR Research Centre, Indian Institute of Science for the use of AV-500 NMR spectrometer. VSM and AK respectively thank UGC and National Academy of Sciences, India for fellowship support.

Keywords

Genetic Algorithm
Quantification
Refocused-INEPT
Spectral simplification

Publisher link

10.1016/j.jmr.2013.06.013

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Cite this

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title = "Fast and accurate quantification using genetic algorithm optimized 1H-13C refocused constant-time INEPT",

abstract = "Using Genetic Algorithm, a global optimization method inspired by nature's evolutionary process, we have improved the quantitative refocused constant-time INEPT experiment (Q-INEPT-CT) of M{\"a}kel{\"a} et al. (JMR 204 (2010) 124-130) with various optimization constraints. The improved 'average polarization transfer' and 'min-max difference' of new delay sets effectively reduces the experimental time by a factor of two (compared with Q-INEPT-CT, M{\"a}kel{\"a} et al.) without compromising on accuracy. We also discuss a quantitative spectral editing technique based on average polarization transfer.",

keywords = "Genetic Algorithm, Quantification, Refocused-INEPT, Spectral simplification",

author = "Manu, \{V. S.\} and Anil Kumar",

note = "Funding Information: We thank NMR Research Centre, Indian Institute of Science for the use of AV-500 NMR spectrometer. VSM and AK respectively thank UGC and National Academy of Sciences, India for fellowship support. ",

year = "2013",

doi = "10.1016/j.jmr.2013.06.013",

language = "English (US)",

volume = "234",

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journal = "Journal of Magnetic Resonance",

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T1 - Fast and accurate quantification using genetic algorithm optimized 1H-13C refocused constant-time INEPT

AU - Manu, V. S.

AU - Kumar, Anil

N1 - Funding Information: We thank NMR Research Centre, Indian Institute of Science for the use of AV-500 NMR spectrometer. VSM and AK respectively thank UGC and National Academy of Sciences, India for fellowship support.

PY - 2013

Y1 - 2013

N2 - Using Genetic Algorithm, a global optimization method inspired by nature's evolutionary process, we have improved the quantitative refocused constant-time INEPT experiment (Q-INEPT-CT) of Mäkelä et al. (JMR 204 (2010) 124-130) with various optimization constraints. The improved 'average polarization transfer' and 'min-max difference' of new delay sets effectively reduces the experimental time by a factor of two (compared with Q-INEPT-CT, Mäkelä et al.) without compromising on accuracy. We also discuss a quantitative spectral editing technique based on average polarization transfer.

AB - Using Genetic Algorithm, a global optimization method inspired by nature's evolutionary process, we have improved the quantitative refocused constant-time INEPT experiment (Q-INEPT-CT) of Mäkelä et al. (JMR 204 (2010) 124-130) with various optimization constraints. The improved 'average polarization transfer' and 'min-max difference' of new delay sets effectively reduces the experimental time by a factor of two (compared with Q-INEPT-CT, Mäkelä et al.) without compromising on accuracy. We also discuss a quantitative spectral editing technique based on average polarization transfer.

KW - Genetic Algorithm

KW - Quantification

KW - Refocused-INEPT

KW - Spectral simplification

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DO - 10.1016/j.jmr.2013.06.013

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JF - Journal of Magnetic Resonance

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