Fascicle-Specific Targeting of Longitudinal Intrafascicular Electrodes for Motor and Sensory Restoration in Upper-Limb Amputees

Jonathan Cheng; Zhi Yang; Cynthia K. Overstreet; Edward Keefer

doi:10.1016/j.hcl.2021.04.004

Fascicle-Specific Targeting of Longitudinal Intrafascicular Electrodes for Motor and Sensory Restoration in Upper-Limb Amputees

Jonathan Cheng, Zhi Yang, Cynthia K. Overstreet, Edward Keefer

Biomedical Engineering

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

Multichannel longitudinal intrafascicular electrode (LIFE) interfaces provide optimized balance of invasiveness and stability for chronic sensory stimulation and motor recording/decoding of peripheral nerve signals. Using a fascicle-specific targeting (FAST)-LIFE approach, where electrodes are individually placed within discrete sensory- and motor-related fascicular subdivisions of the residual ulnar and/or median nerves in an amputated upper limb, FAST-LIFE interfacing can provide discernment of motor intent for individual digit control of a robotic hand, and restoration of touch- and movement-related sensory feedback. The authors describe their findings from clinical studies performed with 6 human amputee trials using FAST-LIFE interfacing of the residual upper limb.

Original language	English (US)
Pages (from-to)	401-414
Number of pages	14
Journal	Hand Clinics
Volume	37
Issue number	3
DOIs	https://doi.org/10.1016/j.hcl.2021.04.004
State	Published - Aug 2021

Bibliographical note

Funding Information:
J. Cheng and E. Keefer have ownership in Nerves Incorporated, which is a sponsor of the clinical studies described in this article using research funding provided by DARPA. Z. Yang is co-founder of, and holds equity in, Fasikl Inc, a sponsor of this project. We owe a great debt of gratitude to the wonderful patients who have given so generously of their time and their well-being by participating in this groundbreaking research. If there are heroes and angels to be found in this work, our patients deserve those accolades without any doubt. Our further efforts and our persistence in this work are now owed to them, as they have sacrificed for all amputees present and future, and we must succeed in bringing FAST-LIFE electrode interfacing to fruition as a standard-of-care clinical treatment in order to fully repay our debt to them.

Keywords

Amputee
Electrical stimulation
Fascicle
Machine learning
Motor decoding
Peripheral nerve
Prosthetic control

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title = "Fascicle-Specific Targeting of Longitudinal Intrafascicular Electrodes for Motor and Sensory Restoration in Upper-Limb Amputees",

abstract = "Multichannel longitudinal intrafascicular electrode (LIFE) interfaces provide optimized balance of invasiveness and stability for chronic sensory stimulation and motor recording/decoding of peripheral nerve signals. Using a fascicle-specific targeting (FAST)-LIFE approach, where electrodes are individually placed within discrete sensory- and motor-related fascicular subdivisions of the residual ulnar and/or median nerves in an amputated upper limb, FAST-LIFE interfacing can provide discernment of motor intent for individual digit control of a robotic hand, and restoration of touch- and movement-related sensory feedback. The authors describe their findings from clinical studies performed with 6 human amputee trials using FAST-LIFE interfacing of the residual upper limb.",

keywords = "Amputee, Electrical stimulation, Fascicle, Machine learning, Motor decoding, Peripheral nerve, Prosthetic control",

author = "Jonathan Cheng and Zhi Yang and Overstreet, {Cynthia K.} and Edward Keefer",

note = "Funding Information: J. Cheng and E. Keefer have ownership in Nerves Incorporated, which is a sponsor of the clinical studies described in this article using research funding provided by DARPA. Z. Yang is co-founder of, and holds equity in, Fasikl Inc, a sponsor of this project. We owe a great debt of gratitude to the wonderful patients who have given so generously of their time and their well-being by participating in this groundbreaking research. If there are heroes and angels to be found in this work, our patients deserve those accolades without any doubt. Our further efforts and our persistence in this work are now owed to them, as they have sacrificed for all amputees present and future, and we must succeed in bringing FAST-LIFE electrode interfacing to fruition as a standard-of-care clinical treatment in order to fully repay our debt to them.",

year = "2021",

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doi = "10.1016/j.hcl.2021.04.004",

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N2 - Multichannel longitudinal intrafascicular electrode (LIFE) interfaces provide optimized balance of invasiveness and stability for chronic sensory stimulation and motor recording/decoding of peripheral nerve signals. Using a fascicle-specific targeting (FAST)-LIFE approach, where electrodes are individually placed within discrete sensory- and motor-related fascicular subdivisions of the residual ulnar and/or median nerves in an amputated upper limb, FAST-LIFE interfacing can provide discernment of motor intent for individual digit control of a robotic hand, and restoration of touch- and movement-related sensory feedback. The authors describe their findings from clinical studies performed with 6 human amputee trials using FAST-LIFE interfacing of the residual upper limb.

AB - Multichannel longitudinal intrafascicular electrode (LIFE) interfaces provide optimized balance of invasiveness and stability for chronic sensory stimulation and motor recording/decoding of peripheral nerve signals. Using a fascicle-specific targeting (FAST)-LIFE approach, where electrodes are individually placed within discrete sensory- and motor-related fascicular subdivisions of the residual ulnar and/or median nerves in an amputated upper limb, FAST-LIFE interfacing can provide discernment of motor intent for individual digit control of a robotic hand, and restoration of touch- and movement-related sensory feedback. The authors describe their findings from clinical studies performed with 6 human amputee trials using FAST-LIFE interfacing of the residual upper limb.

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KW - Machine learning

KW - Motor decoding

KW - Peripheral nerve

KW - Prosthetic control

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Fascicle-Specific Targeting of Longitudinal Intrafascicular Electrodes for Motor and Sensory Restoration in Upper-Limb Amputees

Abstract

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Keywords

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