Family history and brain morphology in schizophrenia: An MRI study

Steven B. Schwarzkopf, Henry A. Nasrallah, Stephen C. Olson, Bernhard Bogerts, Judy A. McLaughlin, Tanmoy Mitra

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


This study examined neuroanatomical differences between male schizophrenic patients with a family history of psychosis (n = 16) and those without such a history (n = 15). Intracranial area, cerebral area, ventricular size, and cortical atrophy were assessed using magnetic resonance imaging (MRI). Third ventricular enlargement was more prevalent in patients than controls (n = 15). Familial and nonfamilial patients differed significantly. Reduced cranial and cerebral areas without ventricular enlargement characterized familial patients, whereas nonfamilial patients showed marked lateral ventricular enlargement without a reduction in cranial/cerebral size.

Original languageEnglish (US)
Pages (from-to)49-60
Number of pages12
JournalPsychiatry Research: Neuroimaging
Issue number1
StatePublished - May 1991


  • Schizophrenia
  • family history
  • magnetic resonance imaging

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